{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:27:02Z","timestamp":1777922822097,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Staphylococcus pseudintermedius<\/jats:italic>\n                    is the primary cause of canine pyoderma and has been associated with diseases in other animals, including human beings. A high prevalence of methicillin and multidrug resistance has been reported in this bacterium in some geographic regions of the United States. Multilocus sequence type (MLST) 68 was implicated, initially, as the major clonal genotype based on a limited number of samples. The objectives of this study were to determine the population genetics of\n                    <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                    isolated from a cross-section of the United States using a seven-locus multilocus sequence typing method, to identify clonal complexes (CCs), and to correlate sequence types with antimicrobial susceptibility profiles. A total of 190\n                    <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                    with 86 different MLSTs were detected and the constituents of three major CCs of methicillin-resistant\n                    <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                    (MRSP), CC68, CC71, and CC84, were identified. Different patterns of resistance were associated with each CC. CC71 from the United States had notable differences with CC71 studied on other continents with chloramphenicol, tetracycline, and trimethoprim\/sulfamethoxazole resistance. Some isolates with resistance to the broadest range of drugs tested, including that to chloramphenicol, had STs unrelated to the major CCs, suggesting the potential for the emergence of new clonal populations of MRSP that are resistant to most therapeutically useful antimicrobials.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0250","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T14:54:33Z","timestamp":1494860073000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Clonal Complexes and Antimicrobial Susceptibility Profiles of\n                    <i>Staphylococcus pseudintermedius<\/i>\n                    Isolates from Dogs in the United States"],"prefix":"10.1177","volume":"24","author":[{"given":"Ricardo","family":"Videla","sequence":"first","affiliation":[{"name":"University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar M.","family":"Solyman","sequence":"additional","affiliation":[{"name":"University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshar","family":"Brahmbhatt","sequence":"additional","affiliation":[{"name":"University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bemis","sequence":"additional","affiliation":[{"name":"University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Kania","sequence":"additional","affiliation":[{"name":"University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.02.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01046.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.01.039"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2300-y"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.02.012"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/jb.158.2.513-516.1984","article-title":"Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus","volume":"158","author":"Hartman B.J.","year":"1984","unstructured":"Hartman B.J., , and Tomasz A.. 1984. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J. Bacteriol., 158:513\u2013516.","journal-title":"J. Bacteriol."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.6.1449"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq078"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02193-06"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1128\/JCM.01288-15","article-title":"Changes in the Population of Methicillin-Resistant Staphylococcus pseudintermedius and Dissemination of Antimicrobial-Resistant Phenotypes in the Netherlands","volume":"54","author":"Duim B.","year":"2016","unstructured":"Duim B., , Verstappen K.M., , Broens E.M., , Laarhoven L.M., , van Duijkeren E., , Hordijk J., , de Heus P., , Spaninks M., , Timmerman A.J., , and Wagenaar J.A.. 2016. Changes in the Population of Methicillin-Resistant Staphylococcus pseudintermedius and Dissemination of Antimicrobial-Resistant Phenotypes in the Netherlands. J. Clin. Microbiol., 54:283\u2013288.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.vetmic.2009.06.029","article-title":"Identification of a predominant multilocus sequence type, pulsed-field gel electrophoresis cluster, and novel staphylococcal chromosomal cassette in clinical isolates of mecA-containing, methicillin-resistant Staphylococcus pseudintermedius","volume":"139","author":"Black C.C.","year":"2009","unstructured":"Black C.C., , Solyman S.M., , Eberlein L.C., , Bemis D.A., , Woron A.M., , and Kania S.A.. 2009. Identification of a predominant multilocus sequence type, pulsed-field gel electrophoresis cluster, and novel staphylococcal chromosomal cassette in clinical isolates of mecA-containing, methicillin-resistant Staphylococcus pseudintermedius. Vet. Microbiol., 139:333\u2013338.","journal-title":"Vet. Microbiol."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02421-12"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01915-08"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.vetmic.2010.01.008","article-title":"Widespread rapid emergence of a distinct methicillin- and multidrug-resistant Staphylococcus pseudintermedius (MRSP) genetic lineage in Europe","volume":"144","author":"Ruscher C.","year":"2010","unstructured":"Ruscher C., , Lubke-Becker A., , Semmler T., , Wleklinski C.G., , Paasch A., , Soba A., , Stamm I., , Kopp P., , Wieler L.H., , and Walther B.. 2010. Widespread rapid emergence of a distinct methicillin- and multidrug-resistant Staphylococcus pseudintermedius (MRSP) genetic lineage in Europe. Vet. Microbiol., 144:340\u2013346.","journal-title":"Vet. Microbiol."},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3389\/fmicb.2016.01599","article-title":"Systematic Review on Global Epidemiology of Methicillin-Resistant Staphylococcus pseudintermedius: inference of Population Structure from Multilocus Sequence Typing Data","volume":"7","author":"Pires Dos Santos T.","year":"2016","unstructured":"Pires Dos Santos T., , Damborg P., , Moodley A., , and Guardabassi L.. 2016. Systematic Review on Global Epidemiology of Methicillin-Resistant Staphylococcus pseudintermedius: inference of Population Structure from Multilocus Sequence Typing Data. Front. Microbiol., 7:1599.","journal-title":"Front. 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