{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:27:04Z","timestamp":1777922824673,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Proteus mirabilis<\/jats:italic>\n                    is the second most common cause of urinary tract infections and is also an important cause of nosocomial infections. TEM-type and CTX-M-type extended-spectrum \u03b2-lactamases (ESBLs) are the most widely distributed in this bacterial species, but minor ESBLs such as the VEB-type have also been identified. The aim of this study was to analyze the genetic environment of the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VEB-4<\/jats:sub>\n                    gene found in a\n                    <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                    clinical isolate recovered in Spain.\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    .\n                    <jats:italic toggle=\"yes\">mirabilis<\/jats:italic>\n                    N2231 showed resistance to penicillins, cephalosporins, and aminoglycosides, remaining susceptible to imipenem, cefoxitin, \u03b2-lactamases inhibitors, and quinolones. Southern blot analysis revealed that\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VEB-4<\/jats:sub>\n                    was located in the chromosome. Analysis of the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VEB-4<\/jats:sub>\n                    genetic context revealed a 15\u2009kb segment 98% identical to the multidrug resistance (MDR) region of a\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    genomic island 1 (SGI1), which included a class 1 integron belonging to the In104 family, previously described in\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VEB-6<\/jats:sub>\n                    -producing\n                    <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                    VB1248.\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VEB-4<\/jats:sub>\n                    was surrounded by repeat elements, transposon Tn\n                    <jats:italic toggle=\"yes\">1721<\/jats:italic>\n                    , and located on a class 1 integron containing\n                    <jats:italic toggle=\"yes\">aacA4-aadB-dfrA1-orfC<\/jats:italic>\n                    genes. The\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VEB-4<\/jats:sub>\n                    gene was inserted in a complex structure of a class 1 integron, which is part of an MDR region of an SGI1, possibly involved in the mobilization of the gene and homologous recombination.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0262","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T10:29:43Z","timestamp":1489746583000},"page":"833-837","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of the Genetic Environment of the\n                    <i>bla<\/i>\n                    <sub>VEB-4<\/sub>\n                    Gene, Associated with a Transposable Region in a\n                    <i>Proteus mirabilis<\/i>\n                    Clinical Isolate"],"prefix":"10.1177","volume":"23","author":[{"given":"Paula","family":"Espinal","sequence":"first","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisenda","family":"Mir\u00f3","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Ramoneda","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Flores","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Rivera","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Coll","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferran","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau and Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau)","place":["Spain"]},{"name":"Universitat Aut\u00f2noma de Barcelona","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"3","article-title":"Proteus mirabilis and urinary tract infections","author":"Schaffer J.N.","year":"2015","unstructured":"Schaffer J.N., , and Pearson M.M.. 2015. Proteus mirabilis and urinary tract infections. Microbiol. Spectr. 3. DOI: 10.1128\/microbiolspec.UTI-0017-2013.","journal-title":"Microbiol. Spectr."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01313-08"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.119"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00047-16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-15"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3284-3290.2004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jegh.2016.02.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3542-3547.2003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.05.002"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn056"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.5.703"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02365-14"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.175-182.2001"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020007"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.3.573"},{"key":"e_1_3_3_17_2","volume-title":"Twenty-Fifth Informational Supplement (M100-S25)","author":"CLSI","year":"2015","unstructured":"CLSI. 2015. Clinical and Laboratory Standards Institute. 2015. Performance Standards for Antimicrobial Susceptibility Testing. Twenty-Fifth Informational Supplement (M100-S25)."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00679-11"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr039"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr335"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh553"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01773-13"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1549-1552.2002"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr286"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr030"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq283"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt100"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00414-09"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3590-3592.2005"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2016.0262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2016.0262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2016.0262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:31:17Z","timestamp":1777667477000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2016.0262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,17]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10,1]]}},"alternative-id":["10.1089\/mdr.2016.0262"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2016.0262","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,17]]}}}