{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:27:05Z","timestamp":1777922825612,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:p>\n                    The emergence of\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    sequence type 131 (ST131) as a multidrug-resistant and virulent pathogen represents a major challenge to public health globally. Recently, the O25b\/ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    producing CTX-M-15 with high virulence potential has been reported worldwide, but has received little attention in Iran. This study is the first in Iran to specifically determine the spread of the O25b\/ST131 clone producing CTX-M-15 among\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates belonging to the B2 phylogenetic group. ST131 clone in phylogenetic group B2 was detected based on PCR detection of ST131-specific single-nucleotide polymorphisms in\n                    <jats:italic toggle=\"yes\">mdh<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">gyrB<\/jats:italic>\n                    . O25b\/ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    clone was confirmed utilizing O25b\/ST131 clone allele-specific PCR for the\n                    <jats:italic toggle=\"yes\">pabB<\/jats:italic>\n                    gene. All group B2\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates were characterized based on antibiotic susceptibility, extended-spectrum \u03b2-lactamase (ESBL) enzymes, and virulence traits. Our results demonstrated that 38 out of the 154 B2 group isolates (24.7%) were identified as belonging to the ST131 clone. Furthermore, of these, 28 isolates (73.6%) were detected as O25b\/ST131 clone. Antibiotic resistance of ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates to ciprofloxacin, gentamicin, cefotaxime, and aztreonam was significantly higher than non-ST131 isolates. Almost all of the O25b\/ST131 isolates with the ability for ESBL production were reported as CTX-M-15 producing (95.5%). Our results showed that the most prevalent virulence trait in ST131 clone was\n                    <jats:italic toggle=\"yes\">ompT<\/jats:italic>\n                    (94.7%). This study is the first to report the prevalence of the CTX-M-15-producing O25b\/ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    in Iran. Our findings reinforce the surveillance of dissemination of ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    clone as a major drug-resistant pathogen and an important new public health threat.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0272","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T12:01:08Z","timestamp":1487246468000},"page":"879-884","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["First Report of Prevalence of CTX-M-15-Producing\n                    <i>Escherichia coli<\/i>\n                    O25b\/ST131 from Iran"],"prefix":"10.1177","volume":"23","author":[{"given":"Mohammad Hasan","family":"Namaei","sequence":"first","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]},{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Ziaee","sequence":"additional","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Salehabadi","sequence":"additional","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malaknaz","family":"Ghannadkafi","sequence":"additional","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Amini","sequence":"additional","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvin","family":"Askari","sequence":"additional","affiliation":[{"name":"Birjand University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.899901"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05824-11"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/653932"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq415"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00346-13"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00125-13"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088374"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00306-11"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu864"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.007"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046547"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01447-15"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.10.4555-4558.2000"},{"key":"e_1_3_3_15_2","first-page":"25692","article-title":"Virulence genes, genetic diversity, antimicrobial susceptibility and phylogenetic background of Escherichia coli isolates","volume":"3","author":"Abdi H.A.","year":"2015","unstructured":"Abdi H.A., , and Ghalehnoo M.R.. 2015. Virulence genes, genetic diversity, antimicrobial susceptibility and phylogenetic background of Escherichia coli isolates. Int. J. Enter. Pathog., 3:25692.","journal-title":"Int. J. Enter. Pathog."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00297-09"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp194"},{"key":"e_1_3_3_18_2","unstructured":"Wikler M.A. 2007. Performance standards for antimicrobial susceptibility testing: seventeenth informational supplement. Clinical and Laboratory Standards Institute. 26th Inform Suppl 2016; 36:M100-S25."},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","unstructured":"Perna N. Glasner J. Burland V. and Plunkett G.III. 2002. Escherichia coli: Virulence Mechanism of a Versatile Pathogen. 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