{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:38:07Z","timestamp":1787564287383,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    During a Spanish surveillance study, a natural variant of a CMY-type \u03b2-lactamase related to CMY-2 with a GluLeu\n                    <jats:sup>217\u2013218<\/jats:sup>\n                    insertion in the \u03a9-loop (designated CMY-54) was found to increase the minimum inhibitory concentractions to \u03b2-lactams in a clinical strain of\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    . The aim of this study was to characterize CMY-54 by genetic, microbiological, and biochemical analysis. The\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-54<\/jats:sub>\n                    gene is encoded by a plasmid of around 100\u2009kb that hybridizes with K and FIB probes. The genetic context of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-54<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-2<\/jats:sub>\n                    genes was found to be very similar.\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    expressing CMY-54 under isogenic conditions showed a clear fourfold to eightfold increase in MICs to penicillins, cefotaxime, ceftazidime, and aztreonam compared with CMY-2. The catalytic efficiencies of pure CMY-2 and CMY-54 proteins correlated with their microbiological parameters. CMY-2 protein was more resistant to thermal denaturation than CMY-54, indicating that the \u03a9-loop of CMY-54 may be wider and more relaxed and probably enables better accommodation of these antimicrobials. Otherwise, the higher stabilization of CMY-2 may induce a slight reduction of the dynamics of this enzyme and primarily affect the hydrolysis of some of the bulkiest antibiotics. In summary, the GluLeu\n                    <jats:sup>217\u2013218<\/jats:sup>\n                    insertion observed in CMY-54 compared to CMY-2 produces a \u03b2-lactamase with a distinctive catalytic efficacy for \u03b2-lactam antimicrobials likely caused by an increased flexibility slightly affecting the active site shape, highlighting the relevance of single mutations on the hydrolytic spectrum in class C \u03b2-lactamases.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0017","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T14:36:54Z","timestamp":1498833414000},"page":"527-533","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased Antimicrobial Resistance in a Novel CMY-54 AmpC-Type Enzyme with a GluLeu\n                    <sup>217\u2013218<\/sup>\n                    Insertion in the \u03a9-Loop"],"prefix":"10.1177","volume":"24","author":[{"given":"Francisco Jos\u00e9","family":"P\u00e9rez-Llarena","sequence":"first","affiliation":[{"name":"Complejo Hospitalario Universitario A Coru\u00f1a","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"V\u00e1zquez-Ucha","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario A Coru\u00f1a","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Kerff","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Li\u00e8ge","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Hospital Universitario Son Espases","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisenda","family":"Mir\u00f3","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau\/IIB-Sant Pau","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda P\u00f3voa","family":"Cabral","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario A Coru\u00f1a","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fleites","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lantero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla-IDIVAL","place":["Spain"]},{"name":"Universidad de Cantabria","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Oliver","sequence":"additional","affiliation":[{"name":"Hospital Universitario Son Espases","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno","family":"Galleni","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Li\u00e8ge","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferr\u00e1n","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau\/IIB-Sant Pau","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Beceiro","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario A Coru\u00f1a","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Bou","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario A Coru\u00f1a","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00013542-200410000-00003","article-title":"Class C \u03b2-lactamases: an increasing problem worldwide","volume":"15","author":"Beceiro A.","year":"2004","unstructured":"Beceiro A., , and Bou G.. 2004. 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