{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:27:58Z","timestamp":1777922878215,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"\n Resistance of\n Salmonella<\/jats:italic>\n Dublin strains to quinolones and tetracycline has been increasing worldwide. Studies regarding the genotypic resistance traits of strains of this serovar isolated in Brazil are scarce. This study aims to examine the genetic characteristics of\n Salmonella<\/jats:italic>\n Dublin strains isolated in Brazil, which are associated with resistance to quinolone and tetracycline. The minimum inhibitory concentrations (MICs) of nalidixic acid, ciprofloxacin, and tetracycline of the 10 strains sensitive and 21 strains resistant to quinolone and tetracycline were determined using Etest.\n \u00ae<\/jats:sup>\n The mutation profiles of the\n gyrA<\/jats:italic>\n ,\n gyrB<\/jats:italic>\n ,\n parC<\/jats:italic>\n , and\n parE<\/jats:italic>\n genes were accessed by sequencing, while the presence of plasmid-mediated quinolone resistance and\n tet<\/jats:italic>\n genes was analyzed by PCR. Quinolone-resistant strains presented the amino acid substitutions Ser96\u2192Tyr, Ser96\u2192Phe, Asp107\u2192Asn, or Asp108\u2192Gly on the\n gyrA<\/jats:italic>\n gene, and the Ser224\u2192Phe and Glu231\u2192Asp mutations on the\n gyrB<\/jats:italic>\n gene. The\n qnrA<\/jats:italic>\n ,\n tet<\/jats:italic>\n (A), and\n tet<\/jats:italic>\n (B) genes were detected in 5, 13, and 6 strains, respectively. Analysis of the MIC values revealed that 1 and 3 strains presented intermediate and resistant MIC profiles to nalidixic acid, respectively; 6 strains presented intermediate MIC profile to ciprofloxacin; and 13 strains presented resistant MIC profile to tetracycline. In the\n Salmonella<\/jats:italic>\n Dublin strains studied, quinolone resistance was mainly related to mutation points that led to target alteration in the\n gyrA<\/jats:italic>\n and\n gyrB<\/jats:italic>\n genes, while tetracycline resistance was associated with the presence of\n tet<\/jats:italic>\n (A) and\/or\n tet<\/jats:italic>\n (B) genes, with the highest resistance levels detected in strains bearing the\n tet<\/jats:italic>\n (B) gene. The presence of the aforementioned genotypic resistance traits in\n Salmonella<\/jats:italic>\n Dublin strains isolated over 33 years in Brazil indicates that ciprofloxacin or tetracycline therapy against such strains may fail.\n <\/jats:p>","DOI":"10.1089\/mdr.2017.0329","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T15:36:56Z","timestamp":1537198616000},"page":"143-151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Genotypic Resistance to Quinolone and Tetracycline in\n Salmonella<\/i>\n Dublin Strains Isolated from Humans and Animals in Brazil"],"prefix":"10.1177","volume":"25","author":[{"given":"Felipe Pinheiro","family":"Vilela","sequence":"first","affiliation":[{"name":"Faculdade de Odontologia de Ribeir\u00e3o Preto\u2013USP","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Nogueira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto\u2013USP","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline","family":"Passaglia","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto\u2013USP","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1lia Prazeres","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Garcia","family":"Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz\u2013FIOCRUZ","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Ribeiro","family":"Tiba Casas","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sueli Aparecida","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Pfrimer","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto\u2013USP","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio","family":"Campioni","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto\u2013USP","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"CDC. 2017. 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