{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:24:34Z","timestamp":1778628274447,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    In view of the changing antibiotic-resistance profiles of\n                    <jats:italic toggle=\"yes\">Streptococcus agalactiae<\/jats:italic>\n                    from tilapia in China, antimicrobial susceptibilities of 75\n                    <jats:italic toggle=\"yes\">S. agalactiae<\/jats:italic>\n                    strains were determined by the disc diffusion method, and cluster analyses of the antibiograms and antibiogram types were performed. All strains displayed multidrug resistance (MDR). The antimicrobial-resistance rates were highest (&gt;90%) to aminoglycosides, sulfonamides, pipemidic acid, and norfloxacin, followed by penicillin, ampicillin, and ciprofloxacin (26.7\u201338.7%); those to furadantin, lincomycin, erythromycin, ofloxacin, tetracycline, and florfenicol were low (&lt;10%), and no resistance to vancomycin, cefalexin, cefoxitin, amoxicillin, medemycin, doxitard, oxytetracycline, rifampin, chloramphenicol, or thiamphenicol was detected. Statistical analysis showed that the resistance rate to ciprofloxacin increased significantly in 2016 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.009), whereas that to trimethoprim\/sulfamethoxazole decreased (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.017). Cluster analyses identified that the strains had 23 antibiogram types (A\u2013W) and clustered in five groups (Groups I\u2013V). The strains with higher antimicrobial resistance mainly clustered in Groups I and II. Our results show that the antibiograms varied with time and by location and that antibiogram types are constantly updating and expanding. Effective measures must be taken to reduce the antimicrobial resistance and spread of MDR strains.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0350","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T14:01:08Z","timestamp":1526047268000},"page":"1431-1439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clustering Analysis of Antibiograms and Antibiogram Types of\n                    <i>Streptococcus agalactiae<\/i>\n                    Strains from Tilapia in China"],"prefix":"10.1177","volume":"24","author":[{"given":"Chan","family":"Liu","sequence":"first","affiliation":[{"name":"South China Sea Fisheries Research Institute","place":["China"]},{"name":"Tianjin Agricultural University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[{"name":"South China Sea Fisheries Research Institute","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pearl River Fisheries Research Institute","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yundan","family":"Xie","sequence":"additional","affiliation":[{"name":"South China Sea Fisheries Research Institute","place":["China"]},{"name":"Tianjin Agricultural University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anxing","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyong","family":"Wang","sequence":"additional","affiliation":[{"name":"South China Sea Fisheries Research Institute","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youlu","family":"Su","sequence":"additional","affiliation":[{"name":"South China Sea Fisheries Research Institute","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/jac\/dkn183","article-title":"The 2008 Garrod Lecture: Antimicrobial resistance - Animals and the environment","volume":"62","author":"Prior L.S.","year":"2008","unstructured":"Prior L.S. 2008. 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