{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:07Z","timestamp":1777922887430,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    strains submitted to the Tuberculosis Reference Center in C\u00f3rdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and ethambutol (0.2%). A total of 1.9% of strains were MDR-TB. Six strains displayed resistance to four drugs, and three strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0353","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:33:27Z","timestamp":1522679607000},"page":"839-843","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Surveillance of Drug-Resistant Tuberculosis in Spain (2001\u20132015)"],"prefix":"10.1177","volume":"24","author":[{"given":"Juan Bautista","family":"Guti\u00e9rrez-Aroca","sequence":"first","affiliation":[{"name":"University of Cordoba","place":["Spain"]},{"name":"Tuberculosis Control Reference Center","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Ruiz","sequence":"additional","affiliation":[{"name":"University of Cordoba","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Vaquero","sequence":"additional","affiliation":[{"name":"University of Cordoba","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Causse","sequence":"additional","affiliation":[{"name":"Tuberculosis Control Reference Center","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Casal","sequence":"additional","affiliation":[{"name":"University of Cordoba","place":["Spain"]},{"name":"Tuberculosis Control Reference Center","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 2017. 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