{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:56:09Z","timestamp":1788990969946,"version":"build-2803163510"},"reference-count":55,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    spp. are health-threatening foodborne pathogens. The increasingly common spread of antibiotic-resistant\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    spp. is a major public healthcare issue worldwide. In this study, we wished to explore (1) antibiotic or polypeptide combinations to inhibit multidrug-resistant\n                    <jats:italic toggle=\"yes\">Salmonella bredeney<\/jats:italic>\n                    and (2) the regulation of cross-resistance and collateral sensitivity of antibiotics and polypeptides. We undertook a study to select antibiotic combinations. Then, we promoted drug-resistant strains of\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    after 15 types of antibiotic treatment. From each evolving population, the\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    strain was exposed to a particular single drug. Then, we analyzed how the evolved\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    strains acquired resistance or susceptibility to other drugs. A total of 105 combinations were tested against\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    following the protocols of CLSI-2016 and EUCAST-2017. The synergistic interactions between drug pairings were diverse. Notably, polypeptides were more likely to be linked to synergistic combinations: 56% (19\/34) of the synergistic pairings were relevant to polypeptides. Simultaneously, macrolides demonstrated antagonism toward polypeptides. The latter were more frequently related to collateral sensitivity than the other drugs because the other 13 drugs sensitized\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    to polypeptides. In an experimental evolution involving 15 drugs, single drug-evolved strains were examined against the other 14 drugs, and the results were compared with the minimal inhibitory concentration of the ancestral strain. Single drug-evolved\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    strains could alter the sensitivity to other drugs, and\n                    <jats:italic toggle=\"yes\">S. bredeney<\/jats:italic>\n                    evolution against antibiotics could sensitize it to polypeptides.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0367","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T11:04:55Z","timestamp":1527159895000},"page":"1450-1459","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Combined Effects and Cross-Interactions of Different Antibiotics and Polypeptides in\n                    <i>Salmonella bredeney<\/i>"],"prefix":"10.1177","volume":"24","author":[{"given":"Xiangyu","family":"Ju","sequence":"first","affiliation":[{"name":"Nanjing Agricultural University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"Han","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxin","family":"Lu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Bie","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.321.5887.356"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208747"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1034"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.07.021"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5352"},{"key":"e_1_3_3_8_2","first-page":"495","article-title":"Preliminary incidence and trends of infection with pathogens transmitted commonly through food-Foodborne Diseases Active Surveillance Network, 10 US sites, 2006\u20132014","volume":"64","author":"Crim S.","year":"2015","unstructured":"Crim S., , Griffin P., , Tauxe R., , Marder E., , Gilliss D., , Cronquist A., , Cartter M., , Tobin-D'Angelo M., , Blythe D., , and Smith K.. 2015. 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Notes from the field: Salmonella bredeney infections linked to a brand of peanut butter\u2014United States, 2012. MMWR Morb. Mortal. Wkly. Rep., 62:107.","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv114"},{"key":"e_1_3_3_40_2","volume-title":"2013 CSTE Annual Conference","author":"Gensheimer K.F.","unstructured":"Gensheimer K.F. Responding to an Outbreak of Salmonella bredeney: a Collaboration Between the FDA, CDC, and State Health Partners. 2013 CSTE Annual Conference, CSTE. Pasadena, CA."},{"key":"e_1_3_3_41_2","first-page":"52","volume-title":"Twenty-sixth informational supplement","author":"Clinical and Laboratory Standards Institute.","year":"2016","unstructured":"Clinical and Laboratory Standards Institute.. 2016. Performance standards for antimicrobial susceptibility testing. In Tertel M.L., , Christopher J.P., , and Phucas A.B. (eds.), Twenty-sixth informational supplement. CLSI document M100-S26. 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