{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:38:40Z","timestamp":1788907120006,"version":"build-2803163510"},"reference-count":49,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,11]]},"abstract":"\n We investigated the occurrence of extended-spectrum \u03b2-lactamase (ESBL) and AmpC-type \u03b2-lactamase (ACBL) producing quinolone-resistant\n Klebsiella pneumoniae<\/jats:italic>\n (KP) in milk samples of apparently healthy buffaloes (\n n<\/jats:italic>\n \u2009=\u2009348) and buffaloes (\n n<\/jats:italic>\n \u2009=\u200919) with evidence of subclinical mastitis from seven districts of West Bengal, India. In total, 12 ESBL producing KP were isolated with\n bla<\/jats:italic>\n CTX-M-15 gene and 7 of them were ACBL producers, as well. The\n bla<\/jats:italic>\n CTX-M-15 genes were carried by transposable element\n ISEcp1<\/jats:italic>\n . The plasmid-mediated quinolone resistance genes\u2014\n qnrS<\/jats:italic>\n ,\n qnrA<\/jats:italic>\n ,\n qnrB<\/jats:italic>\n ,\n qepA<\/jats:italic>\n , and\n aac(6\u2032)-Ib-cr<\/jats:italic>\n were detected in five, one, three, four, and one isolate (s), respectively. In addition, eight isolates carried mutation in gyrase (\n gyrA<\/jats:italic>\n ) and six in topoisomerase IV (\n parC<\/jats:italic>\n ). Resistance markers\/genes for sulfonamide (\n sul<\/jats:italic>\n 1), tetracycline [\n tet<\/jats:italic>\n (A) and\n tet<\/jats:italic>\n (B)], and aminoglycoside (\n aacC2<\/jats:italic>\n ) were also detected in eight, four, and one isolate(s), respectively. The class I integrons identified in five isolates carried\n aad2\/aad5<\/jats:italic>\n and\n dfrA12<\/jats:italic>\n \/\n dfrA17<\/jats:italic>\n gene cassettes. The enterobacterial repetitive intergenic consensus-PCR revealed that all the isolates were genetically diverse and comprised a heterogeneous population. Isolation of multidrug-resistant KP, a typical nosocomial pathogen from buffalo milk, reiterates the need to monitor farm animals for ESBL producing\n Enterobacteriaceae<\/jats:italic>\n and emphasizes on judicious use of antibiotics in animal husbandry sector.\n <\/jats:p>","DOI":"10.1089\/mdr.2017.0368","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T11:38:38Z","timestamp":1521718718000},"page":"1345-1353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Genomic Identity of Fluoroquinolone-Resistant\n bla<\/i>\n CTX-M\n -15<\/i>\n -Type ESBL and pMAmpC \u03b2-Lactamase Producing\n Klebsiella pneumoniae<\/i>\n from Buffalo Milk, India"],"prefix":"10.1177","volume":"24","author":[{"given":"Samiran","family":"Bandyopadhyay","sequence":"first","affiliation":[{"name":"ICAR-Indian Veterinary Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydeep","family":"Banerjee","sequence":"additional","affiliation":[{"name":"ICAR-Indian Veterinary Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debaraj","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"ICAR-Indian Veterinary Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Samanta","sequence":"additional","affiliation":[{"name":"WBUAFS","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achintya","family":"Mahanti","sequence":"additional","affiliation":[{"name":"WBUAFS","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan K.","family":"Dutta","sequence":"additional","affiliation":[{"name":"CAU","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarbaswarup","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Ramakrishna Mission Vivekananda Educational and Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K.","family":"Nanda","sequence":"additional","affiliation":[{"name":"ICAR-Indian Veterinary Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premanshu","family":"Dandapat","sequence":"additional","affiliation":[{"name":"ICAR-Indian Veterinary Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasish","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"ICAR-Indian Veterinary Research Institute","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1469-0691.2009.03018.x","article-title":"Emergence of CTX-M-15 extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae isolates in Bosnia and Herzegovina","volume":"16","author":"Dedeic-Ljubovic A.","year":"2010","unstructured":"Dedeic-Ljubovic A., , Hukic M., , Pfeifer Y., , Witte W., , Padilla E., , Lopez-Ramis I., , and Alberti S.. 2010. Emergence of CTX-M-15 extended-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae isolates in Bosnia and Herzegovina. Clin. Microbiol. Infect., 16:152\u2013156.","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.657-686.2005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1128\/AAC.00247-09","article-title":"Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary health region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections","volume":"53","author":"Pitout J.D.","year":"2009","unstructured":"Pitout J.D., , Gregson D.B., , Campbell L., , and Laupland K.B.. 2009. Molecular characteristics of extended-spectrum-beta-lactamase-producing Escherichia coli isolates causing bacteremia in the Calgary health region from 2000 to 2007: emergence of clone ST131 as a cause of community-acquired infections. Antimicrob. Agents Chemother., 53:2846\u20132851.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s11250-015-0818-3","article-title":"Determination of extended spectrum beta-lactamases\/AmpC beta-lactamases and plasmid-mediated quinolone resistance in Escherichia coli isolates obtained from bovine carcasses in Mexico","volume":"47","author":"Aguilar-Montes de Oca S.","year":"2015","unstructured":"Aguilar-Montes de Oca S., , Talavera-Rojas M., , Soriano-Vargas E., , Barba-Leon J., , and Vazquez-Navarrete J.. 2015. Determination of extended spectrum beta-lactamases\/AmpC beta-lactamases and plasmid-mediated quinolone resistance in Escherichia coli isolates obtained from bovine carcasses in Mexico. Trop. Anim. Health Prod., 47:975\u2013981.","journal-title":"Trop. Anim. Health Prod."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/jac\/dku218","article-title":"Identification of fluoroquinolone-resistant extended-spectrum beta-lactamase (CTX-M-8)-producing Escherichia coli ST224, ST2179 and ST2308 in buffalo (Bubalus bubalis)","volume":"69","author":"Aizawa J.","year":"2014","unstructured":"Aizawa J., , Neuwirt N., , Barbato L., , Neves P.R., , Leigue L., , Padilha J., , Pestana de Castro A.F., , Gregory L., , and Lincopan N.. 2014. Identification of fluoroquinolone-resistant extended-spectrum beta-lactamase (CTX-M-8)-producing Escherichia coli ST224, ST2179 and ST2308 in buffalo (Bubalus bubalis). J. Antimicrob. Chemother., 69:2866\u20132869.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/01652176.2014.984365","article-title":"Co-infection of methicillin-resistant Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus and extended spectrum \u03b2-lactamase producing Escherichia coli in bovine mastitis\u2014three cases reported from India","volume":"35","author":"Bandyopadhyay S.","year":"2015","unstructured":"Bandyopadhyay S., , Samanta I., , Bhattacharyya D., , Nanda P.K., , Kar D., , Chowdhury J., , Dandapat P., , Das A.K., , Batul N., , Mondal B., , Dutta T.K., , Das G., , Das B.C., , Naskar S., , Bandyopadhyay U.K., , Das S.C., , and Bandyopadhyay S.. 2015. Co-infection of methicillin-resistant Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus and extended spectrum \u03b2-lactamase producing Escherichia coli in bovine mastitis\u2014three cases reported from India. Vet. 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Evol."},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.meegid.2016.07.032","article-title":"Molecular signature of extended spectrum \u03b2-lactamase producing Klebsiella pneumoniae isolated from bovine milk in eastern and north-eastern India","volume":"44","author":"Koovapra S.","year":"2016","unstructured":"Koovapra S., , Bandyopadhyay S., , Das G., , Bhattacharyya D., , Banerjee J., , Mahanti A., , Samanta I., , Nanda P.K., , Kumar A., , Mukherjee R., , Dimri U., , and Singh R.K.. 2016. Molecular signature of extended spectrum \u03b2-lactamase producing Klebsiella pneumoniae isolated from bovine milk in eastern and north-eastern India. Infect. Genet. Evol., 44:395\u2013402.","journal-title":"Infect. Genet. 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