{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:09Z","timestamp":1777922889449,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:p>\n                    The emergence and dissemination of carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    (CRKP) isolates and their involvement in several nosocomial outbreaks are of high concern. This study was conducted to investigate the genetic relatedness and molecular determinants of carbapenem resistance in 100 CRKP isolates. Susceptibility to carbapenems as well as other antibiotics was determined by using disk diffusion method. The Modified Hodge test was performed for detection of carbapenemase production. The minimum inhibitory concentrations of selected antibiotics were determined by broth microdilution method. The presence of\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>OXA-48<\/jats:sub>\n                    <\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>KPC<\/jats:sub>\n                    <\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>NDM<\/jats:sub>\n                    <\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>VIM<\/jats:sub>\n                    <\/jats:italic>\n                    carbapenemase genes was examined by PCR, and clonal relatedness of CRKP isolates was investigated by pulsed-field gel electrophoresis (PFGE) analysis.\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>OXA-48<\/jats:sub>\n                    <\/jats:italic>\n                    was the most frequent carbapenemase gene (72%), followed by\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>NDM<\/jats:sub>\n                    <\/jats:italic>\n                    (31%). None of the isolates harbored\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>KPC<\/jats:sub>\n                    <\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>VIM<\/jats:sub>\n                    <\/jats:italic>\n                    genes. PFGE separated the majority of isolates into 10 clusters, including the major clusters A and B, carrying\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>OXA-48<\/jats:sub>\n                    <\/jats:italic>\n                    , and clusters C and D, carrying\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>NDM<\/jats:sub>\n                    <\/jats:italic>\n                    , and 4 isolates had a unique PFGE pattern. An increased rate of colistin resistance (50%) was detected among the isolates. Tigecycline was found to be the most active agent against CRKP isolates. Our results revealed that high prevalence of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    carbapenamses and resistance to colistin are alarming threats, necessitating an immediate action to prevent the spread of carbapenem\u2013colistin-resistant\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    isolates in Iran.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0404","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T13:48:29Z","timestamp":1540302509000},"page":"336-343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Molecular Epidemiology and Drug Resistance Pattern of Carbapenem-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    Isolates from Iran"],"prefix":"10.1177","volume":"25","author":[{"given":"Zeinab","family":"Jafari","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]},{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahad Ali","family":"Harati","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehri","family":"Haeili","sequence":"additional","affiliation":[{"name":"University of Tabriz","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalil","family":"Kardan-Yamchi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirous","family":"Jafari","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Jabalameli","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alipasha","family":"Meysamie","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Mehdi","family":"Feizabadi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Iran"]},{"name":"Tehran University of Medical Sciences","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01061"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Marinelli F. and Genilloud O. 2013. 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