{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:08Z","timestamp":1777922888476,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    The goal of this study was to compare the molecular features of bovine- and human community-acquired extended-spectrum \u03b2-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    in Israel. Bovine ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    were isolated during a point-prevalence study from the main farming locations throughout Israel. Human ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates were collected from community-acquired urinary tract infection cases. Molecular typing was done initially by repetitive extragenic palindromic-PCR. Representative isolates were subjected to next-generation sequencing (NGS) and analyzed for multilocus sequence typing (MLST), core genome MLST (cgMLST),\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    gene allele, and mobile genetic elements (MGEs) surrounding it. Out of the 287 bovine- and 104 community-derived ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates, 44 and 26 isolates were subjected to NGS, respectively. Both populations exhibited a diverse but distinct clonal structure with predominance of several sequence types (STs); two clones, ST-10\/167 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200913) and ST-38 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098), were present. cgMLST analysis of these clones revealed that the majority of isolates exhibited phylogenetic distance (PD) of &gt;178 gene difference from their closest isolate, with the exception of five isolates that exhibited PD of &lt;24 gene difference, including two bovine- to three community-derived isolates. Hence, clonal transmission of ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    between cattle and the community, although uncommon, is likely to have occurred. The\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    gene was identified in 52\/70 (74%) isolates from both cattle and the community and was surrounded by MGEs that were composed mostly of either the Tn\n                    <jats:italic toggle=\"yes\">3<\/jats:italic>\n                    or IS\n                    <jats:italic toggle=\"yes\">1380<\/jats:italic>\n                    families. Thus, MGEs are likely to play an important role in the exchange of resistance genes.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0407","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T16:41:56Z","timestamp":1523983316000},"page":"868-875","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Distinctiveness and Similarities Between Extended-Spectrum \u03b2-Lactamase-Producing\n                    <i>Escherichia coli<\/i>\n                    Isolated from Cattle and the Community in Israel"],"prefix":"10.1177","volume":"24","author":[{"given":"Ziv","family":"Lifshitz","sequence":"first","affiliation":[{"name":"National Center of Infection Control","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na'ama","family":"Sturlesi","sequence":"additional","affiliation":[{"name":"Hebrew University","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Parizade","sequence":"additional","affiliation":[{"name":"Maccabee Health Systems","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo E.","family":"Blum","sequence":"additional","affiliation":[{"name":"Kimron Veterinary Institute","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Gordon","sequence":"additional","affiliation":[{"name":"Ben-Gurion University of the Negev","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Taran","sequence":"additional","affiliation":[{"name":"Maccabee Health Systems","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos","family":"Adler","sequence":"additional","affiliation":[{"name":"National Center of Infection Control","place":["Israel"]},{"name":"Tel-Aviv University","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq415"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11270-016-2833-z","article-title":"Phenotypic and molecular assessment of drug resistance profile and genetic diversity of waterborne Escherichia coli","volume":"227","author":"Wolny-Ko\u0142adka K.","year":"2016","unstructured":"Wolny-Ko\u0142adka K., , Lenart-Boro\u0144 A.. 2016. Phenotypic and molecular assessment of drug resistance profile and genetic diversity of waterborne Escherichia coli. Water Air Soil Pollut., 227:146.","journal-title":"Water Air Soil Pollut."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01446-10"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu785"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01851.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1128\/JCM.01915-15","article-title":"Prevalence, risk factors, and transmission dynamics of extended-spectrum-\u03b2-lactamase-producing Enterobacteriaceae: a National Survey of Cattle Farms in Israel in 2013","volume":"53","author":"Adler A.","year":"2015","unstructured":"Adler A., , Sturlesi N., , Fallach N., , Zilberman-Barzilai D., , Hussein O., , Blum S.E., , Klement E., , Schwaber M.J., , and Carmeli Y.. 2015. Prevalence, risk factors, and transmission dynamics of extended-spectrum-\u03b2-lactamase-producing Enterobacteriaceae: a National Survey of Cattle Farms in Israel in 2013. J. Clin. Microbiol., 53:3515\u20133521.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_3_8_2","unstructured":"The Clinical and Laboratory Standards Institute. 2016. M100S Performance Standards for Antimicrobial Susceptibility Testing. 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