{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:59:46Z","timestamp":1784930386328,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Rapid and accurate detection of carbapenemase-producing isolates are extremely important for management of antimicrobial therapy and the implementation of infection control measures. We evaluated the performance of Carba NP-direct, carbapenem inactivation method (CIM), and the commercial \u03b2-CARBA tests for detection of carbapenemase production in\n                    <jats:italic toggle=\"yes\">Enterobacteriaceae<\/jats:italic>\n                    .\n                    <jats:italic toggle=\"yes\">Enterobacteriaceae<\/jats:italic>\n                    isolates with previously characterized carbapenemase types (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009110) and non-carbapenemase-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200915) isolates were tested. Sensitivities of Carba NP-direct, CIM, and \u03b2-CARBA tests were 99.0%, 92.7%, and 93.6%, respectively, while specificity was 100% for all three tests. For \u03b2-CARBA test, a 60-min incubation time instead of 30 increased the sensitivity to 98.1%, and lessened false negativity, particularly with OXA-48-like producers. Our results showed that Carba NP-direct, CIM, and \u03b2-CARBA tests are useful tools for the reliable detection of carbapenemase activity in enterobacterial isolates. Carba NP-direct is a simple, rapid, and low-cost test for routine use.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2017.0427","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T15:56:13Z","timestamp":1524671773000},"page":"97-102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of Carba NP-Direct, Carbapenem Inactivation Method, and \u03b2-CARBA Tests for Detection of Carbapenemase Production in\n                    <i>Enterobacteriaceae<\/i>"],"prefix":"10.1177","volume":"25","author":[{"given":"Banu","family":"Bayraktar","sequence":"first","affiliation":[{"name":"\u015ei\u015fli Hamidiye Etfal Training and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Bar\u0131\u015f","sequence":"additional","affiliation":[{"name":"\u015ei\u015fli Hamidiye Etfal Training and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fah","family":"Malko\u00e7o\u011flu","sequence":"additional","affiliation":[{"name":"Kocaeli Public Health Laboratory","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Erdemir","sequence":"additional","affiliation":[{"name":"\u015ei\u015fli Hamidiye Etfal Training and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"K\u0131na","sequence":"additional","affiliation":[{"name":"\u015ei\u015fli Hamidiye Etfal Training and Research Hospital","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"45","article-title":"European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working group. 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Available at www.cdc.gov\/drugresistance\/threat-report-2013 (accessed September21 2017)."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/jac\/dks426","article-title":"Strategies for identification of carbapenemase-producing Enterobacteriaceae","volume":"68","author":"Nordmann P.","year":"2013","unstructured":"Nordmann P., , and Poirel L.. 2013. Strategies for identification of carbapenemase-producing Enterobacteriaceae. J. Antimicrob. Chemother., 68:487\u2013489.","journal-title":"J. Antimicrob. 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Microbiol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1809.120355"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.diagmicrobio.2017.05.006","article-title":"Evaluation of the RAPIDEC CARBA NP and \u03b2-CARBA tests for rapid detection of Carbapenemase-producing Enterobacteriaceae","volume":"88","author":"Mancini S.","year":"2017","unstructured":"Mancini S., , Kieffer N., , Poirel L., , and Nordmann P.. 2017. Evaluation of the RAPIDEC CARBA NP and \u03b2-CARBA tests for rapid detection of Carbapenemase-producing Enterobacteriaceae. Diagn. Microbiol. Infect. Dis., 88:293\u2013297.","journal-title":"Diagn. Microbiol. Infect. 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Noncarbapenemase OXA-48 variants (OXA-163 and OXA-405) falsely detected as carbapenemases by the \u03b2 carba test. J. Clin. Microbiol., 55:654\u2013655.","journal-title":"J. Clin. 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