{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:18Z","timestamp":1777922898435,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"\n Antimicrobial resistance has become a serious public health threat throughout the world, and therapeutic options for several infectious diseases are currently limited by the presence of multidrug-resistant (MDR) bacteria. This study was designed to examine the drug resistance patterns, the prevalence of the \u03b2-lactamases, and class 1 integrons in MDR\n Escherichia coli<\/jats:italic>\n isolates from chicken meat in Korea. Among 200 chicken meat samples, 101 isolates were observed to be positive for\n E. coli<\/jats:italic>\n , of which 57 were identified as MDR\n E. coli<\/jats:italic>\n . Among 57 MDR\n E. coli<\/jats:italic>\n isolates, the prevalence of\n bla<\/jats:italic>\n gene,\n bla<\/jats:italic>\n CTX-M-1<\/jats:sub>\n ,\n bla<\/jats:italic>\n CTX-M-14<\/jats:sub>\n , and\n bla<\/jats:italic>\n TEM-1<\/jats:sub>\n , were identified in 2, 4, and 16\n E. coli<\/jats:italic>\n strains, respectively; only 1\n E. coli<\/jats:italic>\n strain had both,\n bla<\/jats:italic>\n TEM-1<\/jats:sub>\n and\n bla<\/jats:italic>\n CTX-M-1<\/jats:sub>\n genes. Twenty-one of the 57 MDR\n E. coli<\/jats:italic>\n isolates also carried class 1 integrons, and 5 different gene cassette arrangements were found in 14 of the 21 class 1 integron-positive isolates. The \u03b2-lactamase-producing\n E. coli<\/jats:italic>\n and integron-positive\n E. coli<\/jats:italic>\n had significantly higher resistance to 16 antimicrobial drugs than the non-\u03b2-lactamase-producing\n E. coli<\/jats:italic>\n and the integron-negative\n E. coli<\/jats:italic>\n (\n p<\/jats:italic>\n \u2009<\u20090.05). Our findings suggest that \u03b2-lactamase and class 1 integrons are widely distributed in\n E. coli<\/jats:italic>\n isolates from chicken meat, and directly contribute to resistance to diverse antimicrobial agents. Therefore, continuous investigation of integron gene cassette arrays will provide useful information regarding antimicrobial resistance mechanisms.\n <\/jats:p>","DOI":"10.1089\/mdr.2018.0019","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T14:01:24Z","timestamp":1529589684000},"page":"1599-1606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and Characterization of \u03b2-Lactamases Genes and Class 1 Integrons in Multidrug-Resistant\n Escherichia coli<\/i>\n Isolates from Chicken Meat in Korea"],"prefix":"10.1177","volume":"24","author":[{"given":"Kwang Won","family":"Seo","sequence":"first","affiliation":[{"name":"Kyungpook National University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Kyungpook National University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Adams M.R. and Moss M.O.. 2008. 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