{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:54:54Z","timestamp":1791874494690,"version":"4.3.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Gram-negative microorganisms are a significant cause of infection in both community and nosocomial settings. The increase, emergence, and spread of antimicrobial resistance among bacteria are the most important health problems worldwide. One of the mechanisms of resistance used by bacteria is biofilm formation, which is also a mechanism of virulence. This study analyzed the possible relationship between antimicrobial resistance and biofilm formation among isolates of three Gram-negative bacteria species. Several relationships were found between the ability to form biofilm and antimicrobial resistance, being different for each species. Indeed, gentamicin and ceftazidime resistance was related to biofilm formation in\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , piperacillin\/tazobactam, and colistin in\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    , and ciprofloxacin in\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    . However, no relationship was observed between global resistance or multidrug-resistance and biofilm formation. In addition, compared with other reported data, the isolates in the present study showed higher rates of antimicrobial resistance. In conclusion, the acquisition of specific antimicrobial resistance can compromise or enhance biofilm formation in several species of Gram-negative bacteria. However, multidrug-resistant isolates do not show a trend to being greater biofilm producers than non-multiresistant isolates.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0027","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T15:26:59Z","timestamp":1535124419000},"page":"72-79","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":278,"title":["Relationship Between Biofilm Formation and Antimicrobial Resistance in Gram-Negative Bacteria"],"prefix":"10.1177","volume":"25","author":[{"given":"Virginio","family":"Cepas","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuly","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Rolo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ardanuy","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge","place":["Spain"]},{"name":"CIBERes (CIBER de Enfermedades Respiratorias)","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge","place":["Spain"]},{"name":"CIBERes (CIBER de Enfermedades Respiratorias)","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Xercavins","sequence":"additional","affiliation":[{"name":"Hospital Mutua de Terrassa","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Horcajada","sequence":"additional","affiliation":[{"name":"Hospital del Mar","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bosch","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]},{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Soto","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]},{"name":"Hospital Cl\u00ednic\u2014Universitat de Barcelona","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-2002-35716","article-title":"Evolution of antimicrobial resistance: impact on antibiotic use","volume":"23","author":"Guillemot D.","year":"2002","unstructured":"Guillemot D., , Cr\u00e9mieux A.C., , and Courvalin P.. 2002. 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