{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:00:13Z","timestamp":1790017213264,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Phytotherapy is an emerging topic of health research, with particular focus on studying the efficiency of essential oils as antimicrobials. In this study, we investigated the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    susceptibility of\n                    <jats:italic toggle=\"yes\">Staphylococcus<\/jats:italic>\n                    strains isolated from newborns to\n                    <jats:italic toggle=\"yes\">Cymbopogon citratus<\/jats:italic>\n                    oil. The\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    susceptibility of the microorganisms to\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    essential oil was compared with the activities of standard antibiotics administered to newborns using disk diffusion and microdilution methods. For\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    assessment, 30 Wistar rats were wounded and subjected to infection of\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    strain DRJ080, followed by treatment with the antibiotic vancomycin,\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    , or carbopol polymer gel (control) for 11 days.\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    accounted for 23.36% of the 107\n                    <jats:italic toggle=\"yes\">Staphylococcus<\/jats:italic>\n                    sp. strains isolated. Both vancomycin and the essential oil of\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    inhibited the growth of all microorganisms\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . The minimum inhibitory and bactericidal concentrations for the\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    oil were 0.625\u2009mg\/mL in all strains tested. The oil had the same therapeutic effectiveness as vancomycin against\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    DRJ080 in rats. Thus,\n                    <jats:italic toggle=\"yes\">Staphylococcus<\/jats:italic>\n                    strains of newborns are sensitive to\n                    <jats:italic toggle=\"yes\">C. citratus<\/jats:italic>\n                    oil, both\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    , demonstrating its potential as an antibiotic alternative.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0047","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T12:06:25Z","timestamp":1564661185000},"page":"1490-1496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Antimicrobial Activity of\n                    <i>Cymbopogon citratus<\/i>\n                    (DC.) Stapf. Against\n                    <i>Staphylococcus<\/i>\n                    spp. Isolated from Newborn Babies in an Intensive Care Unit"],"prefix":"10.1177","volume":"25","author":[{"given":"Jo\u00e3o Batista","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade do Vale do Sapuca\u00ed, Pouso Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Ara\u00fajo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Sapuca\u00ed, Pouso Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Francisley de","family":"Paiva","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Sapuca\u00ed, Pouso Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Faria de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Sapuca\u00ed, Pouso Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Rodrigues dos Anjos","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Sapuca\u00ed, Pouso Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9 Azevedo de","family":"Brito","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Sapuca\u00ed, Pouso Alegre, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"148","article-title":"Risk factors for the development of early neonatal sepsis in a public hospital in Brazil","volume":"18","author":"Goulart A.P.","year":"2006","unstructured":"Goulart A.P., , Valle C.F, , Dal-Pizzol F., , and Cancelier A.C.L. 2006. 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