{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:24Z","timestamp":1777922904218,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      The aim of the study was to investigate possible synergistic effects between several selected, commercially available essential oils and gentamicin against extended-spectrum \u03b2-lactamase (ESBL)-producing and New Delhi metallo-\u03b2-lactamase-1 (NDM-1)-producing\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      ESBLs production was confirmed by double-disk synergy test. Isolates positive for\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-1<\/jats:sub>\n                      gene were found among the tested strains.\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      ATCC\n                      <jats:sup>\u00ae<\/jats:sup>\n                      BAA-1705\u2122 strain was used as a control. The checkerboard method was applied to assess the synergistic and additive action of nine essential oils: caraway, fennel, peppermint, geranium, basil, clove, thyme, clary sage, and lavender, respectively, in combination with gentamicin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our results indicated that peppermint oil combined with gentamicin showed synergistic activity against both control, ESBL-producing and NDM-1-producing isolates. Caraway essential oil demonstrated synergy with gentamicin toward ESBL-producing and additionally gentamicin-resistant strains. The additive effect was observed for gentamicin combined with thyme, fennel, basil, and clary sage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Because of their synergistic activity with gentamicin, peppermint, and caraway oils in particular, can be considered as an alternative or an addition for the control of infections with limited therapeutic options due to multidrug resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2018.0051","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T15:05:36Z","timestamp":1525100736000},"page":"1368-1375","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Preliminary Study on the Antibacterial Activity of Essential Oils Alone and in Combination with Gentamicin Against Extended-Spectrum \u03b2-Lactamase-Producing and New Delhi Metallo-\u03b2-Lactamase-1-Producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    Isolates"],"prefix":"10.1177","volume":"24","author":[{"given":"Pawe\u0142","family":"Kwiatkowski","sequence":"first","affiliation":[{"name":"Pomeranian Medical University in Szczecin","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Pruss","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University in Szczecin","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart\u0142omiej","family":"Grygorcewicz","sequence":"additional","affiliation":[{"name":"West Pomeranian University of Technology","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Wojciuk","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University in Szczecin","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Do\u0142\u0119gowska","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University in Szczecin","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Giedrys-Kalemba","sequence":"additional","affiliation":[{"name":"Pomeranian Medical University in Szczecin","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Kochan","sequence":"additional","affiliation":[{"name":"Medical University of Lodz","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Sienkiewicz","sequence":"additional","affiliation":[{"name":"Medical University of Lodz","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"4","article-title":"Epidemiology and virulence of Klebsiella pneumoniae","author":"Clegg S.","year":"2016","unstructured":"Clegg S., , and Murphy C.N.. 2016. 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