{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:43:52Z","timestamp":1787975032482,"version":"build-2784847793"},"reference-count":37,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"\n We investigated the prevalence and characteristics of extended-spectrum \u03b2-lactamase (ESBL)-producing\n Escherichia coli<\/jats:italic>\n among 258 residents of long-term care facilities (LTCFs) in Japan. Out of 258 fecal samples collected from nine LTCFs between November 2015 and March 2017, we recovered 59 ESBL-producing\n E. coli<\/jats:italic>\n isolates. All isolates carried\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n genes, mainly\n bla<\/jats:italic>\n CTX-M-27<\/jats:sub>\n (42.4%),\n bla<\/jats:italic>\n CTX-M-14<\/jats:sub>\n (23.7%), and\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n (18.6%). The isolates showed 7 serotypes (STs), including ST131 (\n n<\/jats:italic>\n \u2009=\u200949, 83.1%) and ST38 (\n n<\/jats:italic>\n \u2009=\u20094, 6.8%), and 47 (79.7%) out of 49 isolates belonging to ST131 were identified as\n H30<\/jats:italic>\n R. The 59 ESBL producers were divided into four groups, B2 (86.4%), D (8.5%), A (3.4%), and C (1.7%); 44 (74.6%) were epidemic clone B2-O25-ST131\n H30<\/jats:italic>\n R, of which 21, 11, and 6 harbored\n bla<\/jats:italic>\n CTX-M-27<\/jats:sub>\n ,\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n , and\n bla<\/jats:italic>\n CTX-M-14<\/jats:sub>\n , respectively. Most plasmids were of IncF replicon types (\n n<\/jats:italic>\n \u2009=\u200933), and 22\n bla<\/jats:italic>\n CTX-M-27<\/jats:sub>\n -carrying plasmids showed multiple replicon types, including IncFII, FIA, and FIB. The ESBL producers were susceptible to imipenem, amikacin, and fosfomycin, but resistant to ceftazidime (49.2%), and ciprofloxacin (88.1%); in particular, the isolates harboring the\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n gene showed significantly high resistance rate to ceftazidime (\n p<\/jats:italic>\n \u2009<\u20090.01). Our findings indicate that a considerable proportion of the examined LTCF residents carried ESBL-producing\n E. coli<\/jats:italic>\n isolates in feces and had high prevalence of epidemic clone B2-O25-ST131. Furthermore, continuous investigations would be very necessary to monitor actual carriage states of ESBL-producers among the LTCF residents from the viewpoint of both public health and healthcare viewpoints.\n <\/jats:p>","DOI":"10.1089\/mdr.2018.0068","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T15:31:11Z","timestamp":1527089471000},"page":"1513-1520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of CTX-M-Type Extended-Spectrum \u03b2-Lactamase-Producing\n Escherichia coli<\/i>\n B2-O25-ST131\n H30<\/i>\n R Among Residents in Nonacute Care Facilities in Japan"],"prefix":"10.1177","volume":"24","author":[{"given":"Kumiko","family":"Kawamura","sequence":"first","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kitaoka","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Kimura","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Wachino","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Kanazawa Medical University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Murakami","sequence":"additional","affiliation":[{"name":"Gifu University Hospital","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Tokai University School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshichika","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1215093"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.11.003"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01503-13"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv443"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2010.538856"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02929-15"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq463"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt226"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815001879"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.003"},{"key":"e_1_3_4_12_2","unstructured":"Ministry of Health Labour and Welfare. 2016. 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