{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:02:41Z","timestamp":1787752961602,"version":"build-2784847793"},"reference-count":82,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of our study was to characterize and elicit the genetic relatedness of emerging vancomycin-resistant enterococci (VRE) isolated between 2012 and 2015 at a teaching hospital in Debrecen, Hungary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Altogether 43 nonduplicate vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      (VREfm) clinical isolates were obtained. Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry was used for species identification. Isolates showed 100% resistance to ampicillin and ciprofloxacin while 81.4% were resistant to gentamicin. PCR analysis revealed the presence of\n                      <jats:italic toggle=\"yes\">VanB<\/jats:italic>\n                      in 40 and\n                      <jats:italic toggle=\"yes\">VanA<\/jats:italic>\n                      in 3 isolates. Among\n                      <jats:italic toggle=\"yes\">ace<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">agg<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">esp<\/jats:italic>\n                      virulence genes only\n                      <jats:italic toggle=\"yes\">esp<\/jats:italic>\n                      was found in seven cases. Modified microtiter-plate test showed 13 weak and 4 moderate biofilm producer isolates. Pulsed-field gel electrophoresis revealed nine pulsotypes. According to multilocus sequence typing all of the tested isolates belonged to clonal complex 17 (CC17).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We report on the alarming emergence of multidrug-resistant VREfm belonging to CC17 at a tertiary hospital in Eastern Hungary. This is the first report of sequence types 412 and 364 from this region. Although outbreak did not occur the increasing prevalence of VREfm is of concern and dissemination must be prevented with proper infection control measures and regular VRE screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2018.0074","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T11:47:37Z","timestamp":1530272857000},"page":"1559-1567","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of Clinical Vancomycin-Resistant\n                    <i>Enterococcus faecium<\/i>\n                    Isolated in Eastern Hungary"],"prefix":"10.1177","volume":"24","author":[{"given":"Dorottya","family":"Frany\u00f3","sequence":"first","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Kocsi","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vir\u00e1g","family":"Lesinszki","sequence":"additional","affiliation":[{"name":"National Public Health Institute, Budapest, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"P\u00e1szti","sequence":"additional","affiliation":[{"name":"National Public Health Institute, Budapest, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Koz\u00e1k","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin Erzs\u00e9bet","family":"Bukta","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Dombr\u00e1di","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/491711"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01516-07"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00714-11"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.11.3224-3228.2000"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01710-09"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.03.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.21282"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.026385-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.7.4.462"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91037-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807213190307"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00284.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03286-13"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.11.011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.2.325"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1556\/AMicr.50.2003.4.11"},{"key":"e_1_3_3_18_2","first-page":"259","article-title":"A case report of vancomycin-resistant Enterococcus faecalis colonization of a femoral wound in central Europe","volume":"4","author":"Dombr\u00e1di Z.","year":"2009","unstructured":"Dombr\u00e1di Z., , Bodn\u00e1r F., , Orosi P., , Dombr\u00e1di V., , and Szab\u00f3 J.. 2009. 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