{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:26Z","timestamp":1777922906666,"version":"3.51.4"},"reference-count":59,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Quinolones show excellent antibacterial activity against\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    isolates. Recently, however, quinolone resistance has been increasing in bacteria. This study aimed to examine\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , and compare the activity of DC-159a against\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    serovar Typhimurium with that of ciprofloxacin and nalidixic acid. Inhibitory effects of quinolones were assessed by the drug concentration needed to inhibit the supercoiling activity of recombinant DNA gyrases by 50% (IC\n                    <jats:sub>50<\/jats:sub>\n                    ). Dilution methods were used to determine the minimum inhibitory concentration (MIC) of quinolones against two different strains,\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium and\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Enteritidis. The IC\n                    <jats:sub>50<\/jats:sub>\n                    s of DC-159a against mutant DNA gyrases were much lower than those of nalidixic acid and ciprofloxacin. In particular, the IC\n                    <jats:sub>50<\/jats:sub>\n                    of DC-159a against DNA gyrase with double mutation was less than 1\/50 that of ciprofloxacin and nalidixic acid. MICs of DC-159a were higher than those of ciprofloxacin but lower than those of nalidixic acid. However, the estimated MICs of DC-159a against\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    strains with mutant DNA gyrase were lower than those of ciprofloxacin and nalidixic acid. Therefore, DC-159a can be suggested as an antibiotic candidate for treating salmonellosis caused by quinolone-resistant\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    Typhimurium.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0078","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T14:26:07Z","timestamp":1532355967000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibacterial Activity of DC-159a Against\n                    <i>Salmonella<\/i>\n                    Typhimurium"],"prefix":"10.1177","volume":"25","author":[{"given":"Kentaro","family":"Koide","sequence":"first","affiliation":[{"name":"Hokkaido University Research Center for Zoonosis Control","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriporn","family":"Kongsoi","sequence":"additional","affiliation":[{"name":"Hokkaido University Research Center for Zoonosis Control","place":["Japan"]},{"name":"Kasetsart University","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Hokkaido University Research Center for Zoonosis Control","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Hokkaido University Research Center for Zoonosis Control","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Hokkaido University Research Center for Zoonosis Control","place":["Japan"]},{"name":"Hokkaido University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Hokkaido University Research Center for Zoonosis Control","place":["Japan"]},{"name":"Hokkaido University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02770-13"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/650733"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0805.010267"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0787"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/318457"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00002-15"},{"key":"e_1_3_3_8_2","volume-title":"Critically Important Antimicrobials for Human Medicine 4th Revision","author":"World Health Organization","year":"2013","unstructured":"World Health Organization. 2013. 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