{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:26Z","timestamp":1777922906680,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:p>\n                    Carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    (CRKP) has emerged as a formidable health challenge in recent years owing to the shortage of effective antibiotics. Colistin is the last and sometimes the only therapeutic option for CRKP infections. Unfortunately, resistance to colistin monotherapy is likely to develop. CRKP in China reportedly exhibit low rates of resistance to trimethoprim\u2013sulfamethoxazole. The aim of this study was to evaluate the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    efficacy of trimethoprim\u2013sulfamethoxazole in combination with colistin against four CRKP clinical isolates. The trimethoprim\u2013sulfamethoxazole\/colistin combination rapidly killed all four of the tested isolates after 2\u2009h up to 24\u2009h. Trimethoprim\u2013sulfamethoxazole is one of the few remaining antimicrobials with some activity against CRKP. In particular, combined with colistin, trimethoprim\u2013sulfamethoxazole might be promising for the treatment of CRKP infections.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0085","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T10:09:46Z","timestamp":1534327786000},"page":"152-156","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>In Vitro<\/i>\n                    Bactericidal Activity of Trimethoprim\u2013Sulfamethoxazole\/Colistin Combination Against Carbapenem-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    Clinical Isolates"],"prefix":"10.1177","volume":"25","author":[{"given":"Jiachun","family":"Su","sequence":"first","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"National Health and Family Planning Commission","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"National Health and Family Planning Commission","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglan","family":"Guo","sequence":"additional","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"National Health and Family Planning Commission","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"National Health and Family Planning Commission","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"National Health and Family Planning Commission","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"National Health and Family Planning Commission","place":["China"]},{"name":"Fudan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention. 2014. 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