{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:29Z","timestamp":1777922909152,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"\n Background:<\/jats:title>\n \n Streptococcus thoraltensis<\/jats:italic>\n was first isolated from pigs and rabbits. Later, isolation from human oral and nasal cavities and from throat and oropharynx was documented.\n S. thoraltensis<\/jats:italic>\n was isolated from patients with periodontitis, tonsillopharyngitis, and chorioamnionitis suggesting a possible pathological role in human infections. All\n S. thoraltensis<\/jats:italic>\n isolates of animal and human origins were sensitive to vancomycin.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Standard microbiological identification methods, biochemical analysis, and antibiotic susceptibility testing using disk diffusion and E methods were used. Automatic species identification and antibiotic susceptibility testing were carried out using the Vitek 2 compact system. Molecular analysis of vancomycin resistance gene was carried out using a PCR with specific primers for\n vanA<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n We report a healthy young female adult, aged 19 years, with history of exposure to pet rabbit who had nasal colonization with\n S. thoraltensis<\/jats:italic>\n . Identification of\n S. thoraltensis<\/jats:italic>\n was based on traditional microbiological methods (culture, Gram stain, and biochemical tests), and the Vitek 2 compact system with 97% confidence rate. Antibiotic susceptibility testing of the isolate indicated resistance to most antibiotics, including penicillins, cephalosporins, methicillin, and glycopeptides. The minimal inhibitory concentration for vancomycin and teicoplanin was exceptionally high (>256\u2009\u03bcg\/mL). Molecular analysis indicated the absence of\n vanA<\/jats:italic>\n gene in\n S. thoraltensis<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n We report for the first time the isolation of a fully vancomycin-resistant\n S. thoraltensis<\/jats:italic>\n independent of\n vanA<\/jats:italic>\n from a healthy human anterior nasal cavity. The pathological role of this newly identified organism with an exceptionally rare resistance pattern in human infections is yet to be identified.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/mdr.2018.0092","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T11:40:25Z","timestamp":1539776425000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation of Fully Vancomycin-Resistant\n Streptococcus thoraltensis<\/i>\n from the Nasal Cavity of a Healthy Young Adult"],"prefix":"10.1177","volume":"25","author":[{"given":"Mohammad","family":"Al-Tamimi","sequence":"first","affiliation":[{"name":"Hashemite University","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisreen","family":"Himsawi","sequence":"additional","affiliation":[{"name":"Hashemite University","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumana","family":"Abu-Raideh","sequence":"additional","affiliation":[{"name":"Hashemite University","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deaa","family":"Abu jazar","sequence":"additional","affiliation":[{"name":"Hashemite University","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"Al-jawaldeh","sequence":"additional","affiliation":[{"name":"Hashemite University","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-4-1073"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-010-9619-0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.07.045"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijd.2014.03.003"},{"key":"e_1_3_4_6_2","first-page":"298","article-title":"Case report: chorioamnionitis attributed to Streptococcus thoraltensis","volume":"68","author":"Vukonich M.","year":"2015","unstructured":"Vukonich M., , Moline H., , Chaussee M., , Pepito B., , and Huntington M.K.. 2015. 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