{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:30Z","timestamp":1777922910760,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    serovar Enteritidis is the most common cause of human salmonellosis worldwide. In this study, all clinical isolates of\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Enteritidis recovered between January 2008 and June 2014 in a Spanish region (491) were screened for antimicrobial drug resistance and the phage type (PT) was determined for a significant number (265). PT1, PT14b, PT56, PT6, PT4, and PT8 were the predominant PTs, accounting together for 82% of the isolates. A total of 38.3% of the isolates were susceptible to all antimicrobials tested, 46.4% and 6.1% isolates were resistant to nalidixic acid and ampicillin, respectively, and single isolates were resistant to two (ampicillin and nalidixic acid) or six (ampicillin, chloramphenicol, streptomycin, sulfonamides, tetracycline, and trimethoprim) agents. Nalidixic acid resistance was statistically associated with PT1 and PT14b (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05, 95% CI), and ampicillin resistance with PT6\/PT6a (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05, 95% CI). All ampicillin-resistant isolates (30) carried a plasmid-encoded\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    . All except one harbored the virulence plasmid specific of\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Enteritidis (IncFIIA\u2009+\u2009IncFIB; 28 isolates) or a\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    -positive variant herein (IncFIIA + IncFIB; 1 isolate). Five additional\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    plasmids, of the ColE1, IncX, IncF, and IncI incompatibility groups, were identified. The IncI plasmid, found in the single multidrug-resistant isolate, carried the\n                    <jats:italic toggle=\"yes\">strAB<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    genes together with genes of the virulence plasmid, including the\n                    <jats:italic toggle=\"yes\">spv<\/jats:italic>\n                    operon. The obtained results highlight the high diversity of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    plasmids conferring ampicillin resistance in\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Enteritidis, and support clonal expansion as the main cause of nalidixic acid resistance in this serovar.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0139","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T11:38:01Z","timestamp":1539776281000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular Characterization of\n                    <i>Salmonella enterica<\/i>\n                    Serovar Enteritidis, Genetic Basis of Antimicrobial Drug Resistance and Plasmid Diversity in Ampicillin-Resistant Isolates"],"prefix":"10.1177","volume":"25","author":[{"given":"Vanesa","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Universidad de Oviedo","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenia","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Universidad de Oviedo","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Bances","sequence":"additional","affiliation":[{"name":"Consejer\u00eda de Sanidad","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Herrera-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Salud Carlos III","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERSP)","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Herrera-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Salud Carlos III","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Rosario","family":"Rodicio","sequence":"additional","affiliation":[{"name":"Universidad de Oviedo","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2005005"},{"key":"e_1_3_3_3_2","unstructured":"WHO (World Health Organization). 2015. WHO Estimates of the Global Burden of Foodborne Diseases: Foodborne Disease Burden Epidemiology Reference Group 2007\u20132015. Geneva: World Health Organization. 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