{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:57Z","timestamp":1777922937525,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      To evaluate the antibacterial efficacy of double antibiotic paste (DAP), silver nanoparticle (AgNP) gel, and tailored amorphous multiporous bioactive glass (TAMP-BG) in concentrations suitable for regenerative endodontics (RE) against 3-week-old\n                      <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                      biofilms after 24 hours and 7 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Radicular human dentin specimens were prepared and inoculated with\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      to form 3-week-old biofilms. DAP (1\u2009mg\/mL), AgNPs 0.02%, and TAMP-BG 100\u2009mg\/mL, in methylcellulose gel formulations, were used as antimicrobials. The biofilm disruption assay was done followed by quantification of bacterial colony-forming units and scanning electron microscopic analysis. Results showed that 1\u2009mg\/mL of DAP or AgNPs 0.02% provided significant antibiofilm effects at both time intervals. Both DAP and AgNPs significantly reduced bacterial counts and biofilms after 7 days compared with 24 hours. Furthermore, 100\u2009mg\/mL of TAMP-BG had a comparable antibiofilm effect, but it was less potent than DAP and AgNPs at both time intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      DAP (1\u2009mg\/mL), 0.02% AgNPs, and TAMP-BG (100\u2009mg\/mL) can significantly reduce\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      biofilms. However, complete elimination was only possible with DAP and AgNPs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2018.0228","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T11:21:21Z","timestamp":1547205681000},"page":"761-771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of the Efficacy of Three Antimicrobial Agents Used for Regenerative Endodontics: An\n                    <i>In Vitro<\/i>\n                    Study"],"prefix":"10.1177","volume":"25","author":[{"given":"Reem W.","family":"Sadek","sequence":"first","affiliation":[{"name":"Moharam Beik Dental Center, Ministry of Health, Alexandria, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybel M.","family":"Moussa","sequence":"additional","affiliation":[{"name":"Endodontics, Conservative Dentistry Department, Alexandria University, Alexandria, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania M.","family":"El Backly","sequence":"additional","affiliation":[{"name":"Endodontics, Conservative Dentistry Department, Alexandria University, Alexandria, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel Fattah","family":"Hammouda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12039"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12040"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(98)80170-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.04.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/dj4010004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1546.2012.00284.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.10.049"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200405000-00004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00437.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698929"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.09.023"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.08.022"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.01.015"},{"key":"e_1_3_3_15_2","unstructured":"American Association of Endodontist. 2016. 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