{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:54Z","timestamp":1777922934788,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Morganella morganii<\/jats:italic>\n                    SE10MM harboring quinolone resistance determinant\n                    <jats:italic toggle=\"yes\">qnrD<\/jats:italic>\n                    was investigated in our study. An entirely sequenced novel 2,662\u2009bp\n                    <jats:italic toggle=\"yes\">qnrD<\/jats:italic>\n                    -plasmid pSE10MM was identified and deposited at GenBank under accession number KU160530. Nucleic acid sequence of pSE10MM showed 94\u201397% similarity to previously detected\n                    <jats:italic toggle=\"yes\">qnrD-<\/jats:italic>\n                    plasmids of\n                    <jats:italic toggle=\"yes\">Proteus mirabilis<\/jats:italic>\n                    strains. Phylogenetic analysis by Geneious 9.0.5 showed clusters of plasmids with possible common origin. Initial expression of\n                    <jats:italic toggle=\"yes\">qnrD<\/jats:italic>\n                    gene was found 12.5 normalized to\n                    <jats:italic toggle=\"yes\">rpoB<\/jats:italic>\n                    housekeeping gene. Subsequently, a sub-minimum inhibitory concentration (1\u2009mg\/L) ciprofloxacin exposure resulted in a fold change of 30.06 at 24 hours. In contrast,\n                    <jats:italic toggle=\"yes\">qnrD<\/jats:italic>\n                    -plasmid pSE10MM copy number increased in time from 1.1 to 6.63. Chromosomal mutations of\n                    <jats:italic toggle=\"yes\">gyrA<\/jats:italic>\n                    with S83I,\n                    <jats:italic toggle=\"yes\">gyrB<\/jats:italic>\n                    with S463A, and\n                    <jats:italic toggle=\"yes\">parC<\/jats:italic>\n                    with S80I amino acid substitutions were detected, but no other mutations have occurred as a consequence of ciprofloxacin exposure. Elevated expression of\n                    <jats:italic toggle=\"yes\">qnrD<\/jats:italic>\n                    correlated with that of\n                    <jats:italic toggle=\"yes\">recA<\/jats:italic>\n                    in\n                    <jats:italic toggle=\"yes\">M. morganii<\/jats:italic>\n                    during ciprofloxacin exposure, which indicates SOS-dependent regulation of\n                    <jats:italic toggle=\"yes\">qnrD<\/jats:italic>\n                    . Protective effect of QnrD plays a role in fluoroquinolone-resistant strain even in the presence of chromosomal mutations in gyrase and topoisomerase IV.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0245","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T11:38:48Z","timestamp":1542800328000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ciprofloxacin Promoted\n                    <i>qnrD<\/i>\n                    Expression and Phylogenetic Analysis of\n                    <i>qnrD<\/i>\n                    Harboring Plasmids"],"prefix":"10.1177","volume":"25","author":[{"given":"Bela","family":"Kocsis","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ama","family":"Szmolka","sequence":"additional","affiliation":[{"name":"Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"Szabo","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gulyas","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Krist\u00f3f","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Diagnostic Laboratory of Clinical Microbiology, Semmelweis University, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"G\u00f6cz\u0151","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Szabo","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/nyas.12830","article-title":"Mechanism of drug resistance: quinolone resistance","volume":"1354","author":"Hooper D.C.","year":"2015","unstructured":"Hooper D.C., , and Jacoby G.A.. 2015. 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