{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:50Z","timestamp":1777922930682,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:p>\n                    Pneumococcal isolates from adult patients in northern Japan in 2016 were subjected to molecular investigation related to pneumococcal surface protein A (PspA) and drug resistance determinants. Of the 51 isolates, serotype 3\/ST180 was the most prevalent (17.6%), followed by 35B (ST2755\/ST558) (11.8%) and 15A (ST63\/ST7874\/ST13068\/ST13785) (9.8%). Coverage of serotypes by 13-valent conjugate vaccine and 23-valent polysaccharide vaccine was 27.5% and 49%, respectively. All the isolates expressed PspA family 1 or 2 (51% and 49%, respectively). Each serotype was associated with either of the PspA families (\n                    <jats:italic toggle=\"yes\">e.g.<\/jats:italic>\n                    , serotype 3, PspA family 1; serotypes 35B and 15A, PspA family 2). Multidrug resistance (MDR) was found in 84.3% of the isolates. Minimum of one altered penicillin-binding protein gene was detected in 82.4% of isolates, indicating 25.5% non-susceptibility to penicillin. Serotypes 15A and 35B were predominant and demonstrated MDR. An isolate of serotype 15A\/ST13785 (single-locus variant of ST242) was resistant to fluoroquinolones associated with double mutation in the quinolone resistance-determining regions of\n                    <jats:italic toggle=\"yes\">gyrA<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">parC<\/jats:italic>\n                    . The present study indicates the spread of MDR pneumococci represented by isolates of serotypes 3, 15A, and 35B, and prevalence of both PspA family 1 and 2 in isolates obtained from adult patients.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0267","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T14:58:41Z","timestamp":1548341921000},"page":"744-751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Pneumococcal Surface Protein A Family and Genetic\/Antimicrobial Resistance Traits of Non-Invasive Pneumococcal Isolates from Adults in Northern Japan"],"prefix":"10.1177","volume":"25","author":[{"given":"Mitsuyo","family":"Kawaguchiya","sequence":"first","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Urushibara","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiji Soe","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Habadera","sequence":"additional","affiliation":[{"name":"Sapporo Clinical Laboratory, Inc., Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Sapporo Clinical Laboratory, Inc., Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kudo","sequence":"additional","affiliation":[{"name":"Sapporo Clinical Laboratory, Inc., Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobumichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/655828"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001956"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2411.180326"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2007.131485"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2015.11.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1907.121830"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw020"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.068"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3177-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.05.047"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.02.010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/648593"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0941-9"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03344-14"},{"key":"e_1_3_3_16_2","first-page":"21","article-title":"Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014","volume":"15","author":"Sheppard C.","year":"2016","unstructured":"Sheppard C., , Fry N.K., , Mushtaq S., , Woodford N., , Reynolds R., , Janes R., , Pike R., , Hill R., , Kimuli M., , Staves P., , Doumith M., , Harrison T., , and Livermore D.M.. 2016. 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