{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:19:42Z","timestamp":1778879982561,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    As resistance to the \u03b2-lactam class of antibiotics has become a worldwide problem, multidrug-resistant (MDR) human (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009243) and food animal (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009211) isolates from Lagos, Nigeria were further tested to characterize \u03b2-lactamase-encoding genes and plasmid replicons. Four \u03b2-lactamase-encoding genes (\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA<\/jats:sub>\n                    , and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM<\/jats:sub>\n                    ) were detected using PCR-based replicon typing, 13 and 17 different replicons were identified using a subset of MDR\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    from humans (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200948) and animals (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200996), respectively. Replicon types FIB and X2 were detected in equal numbers (2\/48; 4.2% each) from human isolates, while type Y (16\/96; 16.7%) was the most common type from animals. Only two replicon types, FIB and Y, were detected in both groups; all other types were confined to one group or the other, but not both. Using conjugation, replicon type Y, present in three donors, transferred in all three instances, whereas FIA transferred in 75% (3\/4) of the matings. This study showed that \u03b2-lactamase genes were prevalent in MDR\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    from both humans and animals in Nigeria and also contained diverse plasmid replicons. As the replicon-associated genes were mobile, they are likely to continue disseminating among\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    and facilitating transfer of associated \u03b2-lactamase genes in this region.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0305","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T16:39:52Z","timestamp":1563381592000},"page":"1410-1423","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Plasmid Replicons and \u03b2-Lactamase-Encoding Genes of Multidrug-Resistant\n                    <i>Escherichia coli<\/i>\n                    Isolated from Humans and Food Animals in Lagos, Southwest Nigeria"],"prefix":"10.1177","volume":"25","author":[{"given":"Eyitayo O.","family":"Adenipekun","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria."},{"name":"Department of Medical Microbiology and Parasitology, Olabisi Onabanjo University, College of Health Sciences, Sagamu, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene R.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B. Russell Research Center, U.S. National Poultry Research Center, U.S. Department of Agriculture-Agricultural Research Service, Athens, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Hygiene and Zoonoses Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bamidele A.","family":"Iwalokun","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Olabisi Onabanjo University, College of Health Sciences, Sagamu, Nigeria."},{"name":"Molecular Biology and Biotechnology Department, Nigerian Institute of Medical Research, Lagos, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G.","family":"Frye","sequence":"additional","affiliation":[{"name":"Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B. Russell Research Center, U.S. National Poultry Research Center, U.S. Department of Agriculture-Agricultural Research Service, Athens, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B. Russell Research Center, U.S. National Poultry Research Center, U.S. Department of Agriculture-Agricultural Research Service, Athens, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lari M.","family":"Hiott","sequence":"additional","affiliation":[{"name":"Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B. Russell Research Center, U.S. National Poultry Research Center, U.S. Department of Agriculture-Agricultural Research Service, Athens, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffanie A.","family":"Woodley","sequence":"additional","affiliation":[{"name":"Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B. Russell Research Center, U.S. National Poultry Research Center, U.S. Department of Agriculture-Agricultural Research Service, Athens, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"House","sequence":"additional","affiliation":[{"name":"Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Richard B. 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