{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:28:56Z","timestamp":1777922936591,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    Aquatic animals are now recognized to be major hosts of potentially pathogenic\n                    <jats:italic toggle=\"yes\">Laribacter hongkongensis<\/jats:italic>\n                    . A comparative study was carried out among extended-spectrum \u03b2-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">L. hongkongensis<\/jats:italic>\n                    isolated from frogs (47 isolates) and fish (41 isolates) to examine phenotypic and genotypic antimicrobial resistance profiles, integrons, virulence factors, and genetic relatedness. Isolates from frogs showed a higher incidence of antibiotic resistance compared with those from fish for most of the antimicrobials tested, especially trimethoprim\u2013sulfamethoxazole, tetracycline, ciprofloxacin, levofloxacin, and streptomycin. Multidrug-resistant strains were also found more frequently among frog isolates (5.44 traits on average) than among fish isolates (3.29 traits). In frog isolates, class 1 integrons and the resistance genes\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">tetA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">tetR<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">aac(6\u2032)-Ib-cr<\/jats:italic>\n                    showed a clearly higher incidence compared with isolates from fish. In contrast,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    was higher in fish isolates than in frog isolates. Correlation analysis showed that\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">tetA<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">tetR<\/jats:italic>\n                    were significantly associated with class 1 integrons in frog isolates. The correlations indicated a potential co-selection risk of bacterial resistance to antibiotics. In addition, the distribution of three virulence-associated determinants for the type IV bundle-forming pili gene (\n                    <jats:italic toggle=\"yes\">bfpA<\/jats:italic>\n                    ), ferric aerobactin receptor gene (\n                    <jats:italic toggle=\"yes\">iucD<\/jats:italic>\n                    ), and iron-responsive element gene (\n                    <jats:italic toggle=\"yes\">ireA<\/jats:italic>\n                    ) was markedly higher in strains isolated from frogs than in those isolated from fish. No obvious genetic relatedness was observed between both populations. The large differences found in the incidence of antibiotic resistance, integrons along with the multiple resistance genes, virulence factors, and genetic fingerprints determined by pulsed-field gel electrophoresis suggest a high degree of antibiotic resistance and pathogenicity potential of ESBL-producing\n                    <jats:italic toggle=\"yes\">L. hongkongensis<\/jats:italic>\n                    from isolates found in frogs.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0366","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T10:00:30Z","timestamp":1550224830000},"page":"855-864","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Analysis of Antimicrobial Resistance, Integrons, and Virulence Genes Among Extended-Spectrum \u03b2-Lactamase-Positive\n                    <i>Laribacter hongkongensis<\/i>\n                    from Edible Frogs and Freshwater Fish"],"prefix":"10.1177","volume":"25","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leiwen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Nanfang Hospital, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Longgang, Shenzhen, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Feng","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention of Shunde, Foshan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqing","family":"He","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention of Shenzhen, Shenzhen, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China."},{"name":"Department of Nosocomial Infection Administration, Zhujiang Hospital, Southern Medical University, Guangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1128\/JCM.43.2.919-922.2005","article-title":"Ecoepidemiology of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis","volume":"43","author":"Teng J.L.","year":"2005","unstructured":"Teng J.L., , Woo P.C., , Ma S.S., , Sit T.H., , Ng L.T., , Hui W.T., , Lau S.K., , and Yuen K.Y.. 2005. 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