{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:49Z","timestamp":1787008249458,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n                    Bacteria in biofilms are more resistant to antibacterial agents than bacteria in planktonic form. Hence, antibacterial agents should be able to eradicate biofilms to ensure the best outcomes. Little is known about how well many antibacterial agents can disrupt biofilms. In this study, we compared sodium lauryl sulfate (SDS), rhamnolipids (RHL), and\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -acetylcysteine (NAC) for their ability to eradicate mature biofilms and inhibit new biofilm formation against\n                    <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    . SDS and RHL effectively inhibited formation of five bacterial biofilms in a dose-dependent manner, even at concentrations below the minimal inhibitory concentrations (MICs), suggesting that their antibiofilm activities are unrelated to their antibacterial activities. In contrast, NAC at certain concentrations promoted biofilm formation by all bacteria except\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    , whereas at supra-MIC concentrations, it inhibited biofilm formation against the four bacteria, suggesting that its antibiofilm activity depends on its antibacterial activity. NAC was ineffective at eradicating mature\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    biofilms, and it actually promoted their formation at concentrations &gt;10\u2009mg\/mL. Our results suggest that RHL is superior at eradicating biofilms of\n                    <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    ; SDS is more effective against\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    biofilms; and NAC is more effective against\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    biofilms. Our results may help determine which antibiofilm agents are effective against certain bacterial strains and develop agents effective against specific bacterial threats.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0385","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T15:10:58Z","timestamp":1560870658000},"page":"290-299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Activity of Sodium Lauryl Sulfate, Rhamnolipids, and\n                    <i>N<\/i>\n                    -Acetylcysteine Against Biofilms of Five Common Pathogens"],"prefix":"10.1177","volume":"26","author":[{"given":"Yuanna","family":"Shen","sequence":"first","affiliation":[{"name":"Lab of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Li","sequence":"additional","affiliation":[{"name":"Lab of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Chen","sequence":"additional","affiliation":[{"name":"Lab of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Zou","sequence":"additional","affiliation":[{"name":"Lab of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatian","family":"Li","sequence":"additional","affiliation":[{"name":"Lab of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Lab of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2415"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.65"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2018.08.007"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.94"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.46907"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ijantimicag.2018.04.019","article-title":"Prevention of ESKAPE pathogen biofilm formation by antimicrobial peptides WLBU2 and LL37","volume":"52","author":"Lin Q.","year":"2018","unstructured":"Lin Q., , Deslouches B., , Montelaro R.C, , and Di Y.P.. 2018. 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