{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:57:26Z","timestamp":1780459046321,"version":"3.54.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"\n The aim of this study was to determine the molecular epidemiology of plasmid-mediated quinolone resistance (PMQR) determinants in\n Escherichia coli<\/jats:italic>\n ,\n Salmonella enterica<\/jats:italic>\n (\n Salmonella<\/jats:italic>\n spp.),\n Klebsiella pneumoniae<\/jats:italic>\n , and\n Proteus mirabilis.<\/jats:italic>\n Four hundred seventy-two nonrepetitive isolates were collected from different sources in China and screened for the presence of PMQR genes (PMQRs). Then, 49 PMQR producers were selected to study the coexistence of PMQRs and other resistance genes using whole-genome sequencing (WGS). High rates of resistance to tetracycline (93.4%), nalidixic acid (81.5%), and norfloxacin (65.8%) were observed. The predominant PMQRs were\n aac(6\u2032)-Ib-cr<\/jats:italic>\n (28.6%) and\n oqxAB<\/jats:italic>\n (21.4%). The prevalence of PMQR determinants was significantly higher (\n p<\/jats:italic>\n \u2009<\u20090.05) in\n E. coli<\/jats:italic>\n from stockmen (55.9%, 19\/34), pigs (51.1%, 70\/137), and laying hens (43.1%, 28\/65) than that from wild animals (21.7%, 5\/23) and dairy cattle (20.1%, 5\/24). WGS results showed that 89.8% of the PMQR-positive isolates co-harbored \u03b2-lactamase genes, with\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n being the dominant \u03b2-lactamase gene. In\n K. pneumoniae<\/jats:italic>\n , the coexistence rate of\n oqxAB<\/jats:italic>\n and\n qnrB<\/jats:italic>\n with\n fosA<\/jats:italic>\n ,\n bla<\/jats:italic>\n DHA-1<\/jats:sub>\n , and\n bla<\/jats:italic>\n SHV<\/jats:sub>\n was significantly higher than that in\n P. mirabilis<\/jats:italic>\n and\n E. coli<\/jats:italic>\n . In contrast, the coexistence of\n qnrD<\/jats:italic>\n and\n bla<\/jats:italic>\n OXA-1<\/jats:sub>\n was more prominent (\n p<\/jats:italic>\n \u2009<\u20090.001) in\n P. mirabilis<\/jats:italic>\n than in the other two species. Particularly,\n oqxAB<\/jats:italic>\n and\n mcr-1<\/jats:italic>\n had an obvious preference for\n E. coli<\/jats:italic>\n than\n K. pneumonia<\/jats:italic>\n and\n P. mirabilis<\/jats:italic>\n (\n p<\/jats:italic>\n \u2009<\u20090.001), which had not been reported in previous studies on the prevalence of PMQRs.\n <\/jats:p>","DOI":"10.1089\/mdr.2018.0405","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T14:10:28Z","timestamp":1555942228000},"page":"1050-1056","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Characterization of Plasmid-Mediated Quinolone Resistance in Gram-Negative Bacterial Strains from Animals and Humans in China"],"prefix":"10.1177","volume":"25","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Tuo","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwei","family":"Lei","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Xie","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Gu","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2016.09.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07322-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.801-803.2005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1178-1182.2006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01400-08"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7459-7_22"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1347"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00339-07"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku340"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00024-18"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.02.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00024"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S160720"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0033"},{"key":"e_1_3_3_16_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2010. 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