{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:21:26Z","timestamp":1781871686080,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p>\n                    Hypervirulent\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    typically presents as a community-acquired infection causing a liver abscess. It is often associated with\n                    <jats:italic toggle=\"yes\">rmp<\/jats:italic>\n                    A and\n                    <jats:italic toggle=\"yes\">mag<\/jats:italic>\n                    A genes and confers a mucoid phenotype. Our aim was to evaluate the clinical presentation and antibiotic resistance of hypervirulent\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    (hvKP) of health care-associated origin. The study was performed on 414\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    isolates recovered from patients that visited our hospital from December 2013 through November 2015. Hypervirulence was determined by the presence of a hypermucoviscous phenotype, in 155 isolates (37.4%). We compared health care-associated hvKP infections with community-acquired infections. The hypermucoviscous phenotype was 60 isolates (24.2%) in health care-associated infection and 90 isolates (53.8%) in community-acquired infection. Respiratory infection was the most common source of health care-associated\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    . Antibiotic resistance was higher in health care-associated hvKP infections, which were more frequently associated with non-K1\/K2 serotypes and less frequently associated with\n                    <jats:italic toggle=\"yes\">rmpA<\/jats:italic>\n                    gene. In our study, 38% of hvKP was health care associated. Pneumonia is the most common infection, besides intraabdominal infection, in community-originating strains. These results suggest that health care-associated hvKP may have different microbiological characteristics from classical community-associated infections. Further investigation is needed for other virulent factors associated with health care-associated hvKP.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2018.0423","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T10:44:11Z","timestamp":1557312251000},"page":"1204-1209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Antibiotic Resistance and Clinical Presentation of Health Care-Associated Hypervirulent\n                    <i>Klebsiella pneumoniae<\/i>\n                    Infection in Korea"],"prefix":"10.1177","volume":"25","author":[{"given":"Miri","family":"Hyun","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Yeol","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namhee","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Dongsan Medical Center, School of Medicine, Keimyung University, Daegu, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01019-15"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70205-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/503420"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.11.008"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00676-11"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05658-11"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801004010005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46964-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801105010107"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/519262"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0802.010025"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008050"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01667-13"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit675"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02173-15"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02523-14"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2551-2"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3160-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01150-06"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.04.007"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01127-16"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.07.010"}],"container-title":["Microbial 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