{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:28Z","timestamp":1777922968195,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      This study aimed to characterize the molecular mechanism of resistance to gentamicin among penicillin-resistant, ampicillin-susceptible\n                      <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                      (PRASEF) isolates by investigating the presence of the\n                      <jats:italic toggle=\"yes\">aac(6\u2032)-Ie-aph(2\u2032\u2032)-Ia<\/jats:italic>\n                      gene. The co-resistance to antimicrobials of other classes was also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 151 isolates evaluated, 70 were PRASEF and 81 were penicillin-susceptible and ampicillin-susceptible\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      (PSASEF). No \u03b2-lactamase producing isolate was detected. Eighty-three (55.0%) and 35 (23.2%) out of the 151\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      isolates showed high-level gentamicin resistance (HLGR) and high-level streptomycin resistance (HLSR) phenotypes. However, a significantly higher rate of PRASEF (88.6%) showed HLGR phenotype in comparison with PSASEF (23.5%) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Conversely, a significantly lower rate of PRASEF (14.3%) showing HLSR was observed in comparison with PSASEF (30.9%) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02). The prevalence of isolates displaying multidrug resistance (MDR) phenotype was significantly higher (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) in the group of PRASEF (81.4%) than in PSASEF (18.6%). The majority of PSASEF (61.9%) and PRASEF (90.3%) isolates showing HLGR phenotype was harboring the\n                      <jats:italic toggle=\"yes\">aac(6\u2032)-Ie-aph(2\u2032\u2032)-Ia<\/jats:italic>\n                      gene, which encodes a bifunctional enzyme that inactivates all aminoglycosides except streptomycin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">aac(6\u2032)-Ie-aph(2\u2032\u2032)-Ia<\/jats:italic>\n                      gene was prevalent among the Brazilian PRASEF isolates that usually exhibit co-resistance to gentamicin and to multiple other drugs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2018.0466","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T16:09:55Z","timestamp":1564502995000},"page":"1275-1281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["High Prevalence of the\n                    <i>aac(6\u2032)-Ie-aph(2\u2032\u2032)-Ia<\/i>\n                    Gene in Hospital Isolates of\n                    <i>Enterococcus faecalis<\/i>\n                    Co-Resistant to Gentamicin and Penicillin"],"prefix":"10.1177","volume":"25","author":[{"given":"Luciano Bernardino da","family":"Costa","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Franco","family":"Cor\u00e1","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Ederson Lopes","family":"Correa","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Cabrini","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Ribeiro","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."},{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia de Rond\u00f4nia, Colorado do Oeste, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Gon\u00e7alves","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Agudelo Higuita N.I. and Huycke M.M. 2014. Enterococcal Disease Epidemiology and Implications for Treatment. In Gilmore M.S. Clewell D.B. Ike Y. and Shankar N. (ed.) Enterococci: From Commensals to Leading Causes of Drug Resistant Infection. Massachusetts Eye and Ear Infirmary Boston. Available at www.ncbi.nlm.nih.gov\/books\/NBK190429."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"e_1_3_3_4_2","unstructured":"European Centre for Disease Prevention and ECDC. Control. 2013. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals. Stockholm. Available at www.ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/healthcare-associated-infections-antimicrobial-use-PPS.pdf."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000582"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1128\/9781555816728.ch21","volume-title":"EnterococcusManual of Clinical Microbiology","author":"Teixeira L.M.","year":"2011","unstructured":"Teixeira L.M., , Carvalho M.G, , Shewmaker P.L, , and Facklam R.R. 2011. Enterococcus. 10th ed. In Versalovic J., , Carroll K.C., , Funke G., , Jorgensen J.H., , Landry M.L., , and Warnock D.W. (ed.), Manual of Clinical Microbiology. 10th ed. ASM Press, Washington, pp. 350\u2013364.","edition":"10"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.21282"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1086\/313949","article-title":"Aminoglycoside resistance in enterococci","volume":"31","author":"Chow, J.W","year":"2000","unstructured":"Chow, J.W. 2000. Aminoglycoside resistance in enterococci. Clin. Infect. Dis. 31:586\u2013589.","journal-title":"Clin. Infect. Dis"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/clinids\/12.4.644","article-title":"High-level gentamicin resistance in Enterococcus: microbiology, genetic basis and epidemiology","volume":"12","author":"Patterson J.E.","year":"1990","unstructured":"Patterson J.E., , and Zervos M.J. 1990. High-level gentamicin resistance in Enterococcus: microbiology, genetic basis and epidemiology. Rev. Infect. Dis. 12:644\u2013652.","journal-title":"Rev. Infect. Dis"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1128\/AAC.43.10.2542","article-title":"Antimicrobial susceptibility patterns of enterococci causing infections in Europe","volume":"43","author":"Schouten M.A.","year":"1999","unstructured":"Schouten M.A., , Voss A., , and Hoogkamp-Korstanje J.A. 1999. Antimicrobial susceptibility patterns of enterococci causing infections in Europe. The European VRE study group. Antimicrob. Agents Chemother. 43:2542\u20132546.","journal-title":"The European VRE study group. Antimicrob. Agents Chemother"},{"key":"e_1_3_3_11_2","unstructured":"European Centre for Disease Prevention and ECDC. Control. 2017. Antimicrobial resistance surveillance in Europe 2016. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm. Available at www.ecdc.europa.eu\/en\/publications-data\/antimicrobial-resistance-surveillance-europe-2016."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.430-450.2003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/jac\/dki427","article-title":"Spread of an unusual penicillin and imipenem resistant but ampicillin-susceptible phenotype among Enterococcus faecalis clinical isolates","volume":"57","author":"Metzidie E.","year":"2006","unstructured":"Metzidie E., , Manolis E.N, , Pournaras S., , Sofianou D., , and Tsarkis A. 2006. Spread of an unusual penicillin and imipenem resistant but ampicillin-susceptible phenotype among Enterococcus faecalis clinical isolates. J. Antimicrob. Chemother. 57:158\u2013160.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1128\/JCM.01252-10","article-title":"Gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility: diagnostic and therapeutic implications","volume":"48","author":"Guardabassi L.","year":"2010","unstructured":"Guardabassi L., , Larsen J., , Skov R., , and Schonheyder H.C. 2010. Gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility: diagnostic and therapeutic implications. J. Clin. Microbiol. 48:3820\u20133821.","journal-title":"J. Clin. Microbiol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1128\/JCM.01246-12","article-title":"Ampicillin susceptibility can predict in vitro susceptibility of penicillin-resistant, ampicillin-susceptible Enterococcus faecalis isolates to amoxicillin but not to imipenem and piperacillin","volume":"50","author":"Concei\u00e7\u00e3o N.","year":"2012","unstructured":"Concei\u00e7\u00e3o N., , C.Oliveira C.H.B, , Silva L.E.P, , Souza L.R.C, , and Oliveira A.G. 2012. Ampicillin susceptibility can predict in vitro susceptibility of penicillin-resistant, ampicillin-susceptible Enterococcus faecalis isolates to amoxicillin but not to imipenem and piperacillin. J. Clin. Microbiol. 50:3729\u20133731.","journal-title":"J. Clin. Microbiol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.33073\/pjm-2012-020","article-title":"Penicillin resistance in Enterococcus faecalis: molecular determinants and epidemiology","volume":"61","author":"Gawryszewska I.","year":"2012","unstructured":"Gawryszewska I., , Hryniewicz W., , and Sadowy E. 2012. Penicillin resistance in Enterococcus faecalis: molecular determinants and epidemiology. Pol. J. Microbiol. 61:153\u2013160.","journal-title":"Pol. J. Microbiol"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"fnw044","DOI":"10.1093\/femsle\/fnw044","article-title":"Evaluation of polymorphisms in pbp4 gene and genetic diversity in penicillin-resistant, ampicillin-susceptible Enterococcus faecalis from hospitals in different states in Brazil","volume":"363","author":"Infante V.H.P.","year":"2016","unstructured":"Infante V.H.P., , Concei\u00e7\u00e3o N., , Oliveira A.G, , and Darini A.L.C. 2016. Evaluation of polymorphisms in pbp4 gene and genetic diversity in penicillin-resistant, ampicillin-susceptible Enterococcus faecalis from hospitals in different states in Brazil. FEMS Microbiol. Lett. 363:fnw044.","journal-title":"FEMS Microbiol. Lett"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.meegid.2014.10.018","article-title":"Penicillin-resistant, ampicillin-susceptible Enterococcus faecalis of hospital origin: pbp4 gene polymorphism and genetic diversity","volume":"28","author":"Concei\u00e7\u00e3o N.","year":"2014","unstructured":"Concei\u00e7\u00e3o N., , Silva L.E.P, , Darini A.L, , Pitondo-Silva A., , and Oliveira A.G. 2014. Penicillin-resistant, ampicillin-susceptible Enterococcus faecalis of hospital origin: pbp4 gene polymorphism and genetic diversity. Infect. Genet. Evol. 28:289\u2013295.","journal-title":"Infect. Genet. Evol"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.1.24-27.1995"},{"key":"e_1_3_3_21_2","unstructured":"CLSI. 2015. Performance Standards for Antimicrobial Susceptibility Testing; 25th Informational Supplement. M100\u2013S125. Clinical and Laboratory Standards Institute Wayne PA."},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1128\/AAC.47.4.1423-1426.2003","article-title":"Multiplex PCR for detection of aminoglycoside resistance genes in enterococci","volume":"47","author":"Vakulenko S.B.","year":"2003","unstructured":"Vakulenko S.B., , Donabedian S.M, , Voskresenskiy A.M, , Zervos M.J, , Lerner S.A, , and Chow J.W. 2003. Multiplex PCR for detection of aminoglycoside resistance genes in enterococci. Antimicrob. Agents Chemother. 47:1423\u20131426.","journal-title":"Antimicrob. Agents Chemother"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/jac\/dkt270","article-title":"Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis","volume":"68","author":"Starikova I.","year":"2013","unstructured":"Starikova I., , Al-Haroni M., , Werner G., , Roberts A.P, , Sorum V., , Nielsen M.K, , and Johnsen P.J. 2013. Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis. J. Antimicrob. Chemother. 68:2755\u20132765.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftx021","article-title":"Distribution of antimicrobial resistance determinants, virulence-associated factors and clustered regularly interspaced palindromic repeats loci in isolates of Enterococcus faecalis from various settings and genetic lineages","volume":"75","author":"Gawryszewska I.","year":"2017","unstructured":"Gawryszewska I., , Malinowska K., , Kuch A., , Chrobak-Chmiel D., , Laniewska-Trokenheim L., , Hryniewicz W., , and Sadowy E. 2017. Distribution of antimicrobial resistance determinants, virulence-associated factors and clustered regularly interspaced palindromic repeats loci in isolates of Enterococcus faecalis from various settings and genetic lineages. Pathog. Dis. 75. DOI: 10.1093\/femspd\/ftx021.","journal-title":"Pathog. Dis"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2006.12.265"},{"key":"e_1_3_3_26_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jiac.2015.09.003","article-title":"High-level aminoglycoside resistance in Enterococcus faecalis and Enterococcus faecium causing invasive infection: twelve-year surveillance in the Minami Ibaraki Area","volume":"22","author":"Osuka H.","year":"2016","unstructured":"Osuka H., , Nakajima J., , Oishi T., , Funayama Y., , Ebihara T., , Ishikawa H., , Saito K., , Koganemaru H., , and Hitomi S. 2016. High-level aminoglycoside resistance in Enterococcus faecalis and Enterococcus faecium causing invasive infection: twelve-year surveillance in the Minami Ibaraki Area. J. Infect. Chemother. 22:61\u201363.","journal-title":"J. Infect. Chemother"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1128\/JCM.02526-09","article-title":"Molecular Epidemiology of Vancomycin-Resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals","volume":"48","author":"Panesso D.","year":"2010","unstructured":"Panesso D., , Reyes J., , Rinc\u00f3n S., , Galloway-Pe\u00f1a J., , Zurita J., , Carrillo C., , Merentes A., , Guzm\u00e1n M., , Adachi J.A, , Murray B.E, , and Arias C.A. 2010. Molecular Epidemiology of Vancomycin-Resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals. J. Clin. Microbiol. 48:1562\u20131569.","journal-title":"J. Clin. Microbiol"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/jac\/dki347","article-title":"Molecular epidemiology of high-level aminoglycoside-resistant enterococci isolated from patients in a university hospital in southern Italy","volume":"56","author":"Zarrilli R.","year":"2005","unstructured":"Zarrilli R., , Tripodi M.F, , Di Popolo A., , Fortunato R., , Bagattini M., , Crispino M., , Florio A., , Triassi M., , and Utili R. 2005. Molecular epidemiology of high-level aminoglycoside-resistant enterococci isolated from patients in a university hospital in southern Italy. J. Antimicrob. Chemother. 56:827\u2013835.","journal-title":"J. Antimicrob. Chemother"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jiph.2013.01.001","article-title":"High level of gentamicin resistance (HLGR) among Enterococcus strains isolated from clinical specimens","volume":"6","author":"Dadfarma N.","year":"2013","unstructured":"Dadfarma N., , Fooladi A.A.I, , Oskoui M., , and Mahmoodzadeh H. 2013. High level of gentamicin resistance (HLGR) among Enterococcus strains isolated from clinical specimens. J. Infec. Public. Health. 6:202\u2013208.","journal-title":"J. Infec. Public. Health"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ijantimicag.2018.08.025","article-title":"Structure analysis of transposons carrying aac(6\u2032)-Ie-aph(2\u2032\u2032)-Ia gene in Enterococcus faecalis isolated in Beijing China and comparison of their transfer efficiency","volume":"52","author":"Zhang J.M.","year":"2018","unstructured":"Zhang J.M., , Wang Q., , Han T.Y, , Liu J.H, , Hu X.X, , Qiao F., , Yang X.Y, , Li C.R, , and You X.F. 2018. Structure analysis of transposons carrying aac(6\u2032)-Ie-aph(2\u2032\u2032)-Ia gene in Enterococcus faecalis isolated in Beijing China and comparison of their transfer efficiency. Int. J. Antimicrob. Agents. 52:799\u2013804.","journal-title":"Int. J. Antimicrob. Agents"},{"key":"e_1_3_3_31_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1128\/JCM.03286-13","article-title":"Molecular epidemiology of enterococcal bacteremia in Australia - for the Australian group on antimicrobial resistance","volume":"52","author":"Coombs G.W.","year":"2014","unstructured":"Coombs G.W., , Pearson J.C, , D.A.Daley, Le T., , Robinson O.J, , Gottlieb T., , Howden B.P, , Johnson P.D, , Bennett C.M, , Stinear T.P, , and Turnidge J.D. 2014. Molecular epidemiology of enterococcal bacteremia in Australia - for the Australian group on antimicrobial resistance. J. Clin. Microbiol. 52:897\u2013905.","journal-title":"J. Clin. Microbiol"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1590\/S0100-879X2008001000010","article-title":"Clinical, epidemiological, and microbiological characteristics of bacteremia caused by high-level gentamicin-resistant Enterococcus faecalis","volume":"41","author":"Vigani A.G.","year":"2008","unstructured":"Vigani A.G., , Macedo A.O, , Bratfich O.J, , Stucchi R.S.B, , and Moretti M.L. 2008. Clinical, epidemiological, and microbiological characteristics of bacteremia caused by high-level gentamicin-resistant Enterococcus faecalis. Braz. J. Med. Biol. Res. 41:890\u2013895.","journal-title":"Braz. J. Med. Biol. Res"},{"key":"e_1_3_3_33_2","volume-title":"Enterococcus","author":"Padmasini E.","unstructured":"Padmasini E., , Padmaraj R., , and Ramesh S.S. 2014. High Level aminoglycoside resistance and distribution of aminoglycoside resistant genes among clinical isolates of Enterococcus. species in Chennai, India. Sci. World J. 2014: 32, 9157."},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2009.0917"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1128\/AAC.42.11.2889","article-title":"Diversity of structures carrying the high-level gentamicin resistance gene (aac6-aph2) in Enterococcus faecalis strains isolated in France","volume":"42","author":"Casetta A.","year":"1998","unstructured":"Casetta A., , Hoi A.B, , Cesp\u00e9d\u00e8s G., , and Horaud T. 1998. Diversity of structures carrying the high-level gentamicin resistance gene (aac6-aph2) in Enterococcus faecalis strains isolated in France. Antimicrob. Agents Chemother. 42:2889\u20132892.","journal-title":"Antimicrob. Agents Chemother"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03226.x"},{"key":"e_1_3_3_37_2","volume-title":"Front. Microbiol","author":"Novais C.","year":"2016","unstructured":"Novais C., , Tedim A.P, , Lanza V.F, , Freitas A.R, , Silveira E., , Escada R., , Roberts A.P, , Al-Haroni M., , Baqro F., , Peixe L., , and Coque T.M. 2016. Co-diversification of Enterococcus faecium core genomes and PBP5: evidences of pbp5 horizontal transfer. Front. Microbiol. 7:1581."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02596-05"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2018.0466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2018.0466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2018.0466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:34:47Z","timestamp":1777667687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2018.0466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1089\/mdr.2018.0466"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2018.0466","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]}}}