{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:14Z","timestamp":1777922954630,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      A hospital outbreak of\n                      <jats:italic toggle=\"yes\">Klebsiella pneumonia<\/jats:italic>\n                      e carbapenemase (KPC)-producing\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      (KPN) linked with an index case of community-acquired infection occurred in an urban tertiary care hospital in Seoul, South Korea. Therefore, we performed an outbreak investigation and whole genome sequencing (WGS) analysis to trace the outbreak and investigate the molecular characteristics of the isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      From October 2014 to January 2015, we identified a cluster of three patients in the neurosurgery ward with sputum cultures positive for carbapenem-resistant KPN. An epidemiological investigation, including pulsed-field gel electrophoresis analysis was performed to trace the origins of this outbreak. The index patient's infection was community acquired. Active surveillance cultures using perirectal swabbing from exposed patients, identified one additional patient with KPC-producing KPN colonization. WGS analyses using PacBio RSII instruments were performed for four linked isolates. WGS revealed a genetic linkage of the four isolates belonging to the same sequence type (ST307). All KPN isolates harbored conjugative resistance plasmids, which has\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>KPC-2<\/jats:sub>\n                      carbapenemase genes contained within the Tn\n                      <jats:italic toggle=\"yes\">4401<\/jats:italic>\n                      \u201ca\u201d isoform and other resistance genes. However, WGS showed only three isolates among four KPC-producing KPN were originated from a common origin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This report demonstrates the challenge that KPC-2-producing KPN with the conjugative resistance plasmid may spread not only in hospitals but also in community, and WGS can help to accurately characterize the outbreak.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2018.0475","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T10:38:48Z","timestamp":1563878328000},"page":"1475-1483","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["An Outbreak of KPC-Producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    Linked with an Index Case of Community-Acquired KPC-Producing Isolate: Epidemiological Investigation and Whole Genome Sequencing Analysis"],"prefix":"10.1177","volume":"25","author":[{"given":"Je Eun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."},{"name":"Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeyoung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."},{"name":"AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Ha","sequence":"additional","affiliation":[{"name":"Infection Control Unit, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wooyong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Su","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea."},{"name":"AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Infection Control Unit, Yonsei University College of Medicine, Seoul, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongeun","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South 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