{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:29Z","timestamp":1777922969471,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Colistin became the primary treatment option for Acinetobacters that had developed a high rate of resistance to carbapenems which were the first-line therapy in the past, and now Acinetobacters become resistant to nearly all antibiotics. Because of the resistance potential to colistin and the concerns about toxicity, especially for high doses, colistin combination therapies are preferred nowadays. In this study, we aimed to investigate whether combinations of colistin with meropenem, sulbactam, fosfomycin, vancomycin, and minocycline are synergic or not and to determine minocycline susceptibility rate, which is not in use in our country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>For the studied 23 Acinetobacter strains, the highest synergy was between colistin and vancomycin, which was shown in 4 (17.4%) strains. The synergy of colistin with meropenem and fosfomycin was detected for 1 (4.3%) strain, the synergy of colistin with minocycline was detected for 2 (8.6%) strains, and no synergy was detected for colistin\u2013sulbactam combination. All the strains were susceptible to minocycline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>None of the antibiotic combinations was antagonistic. They had synergistic and additive interactions. Thus, these combinations can be used in clinical practices. The remarkable synergistic interaction of colistin\u2013vancomycin combination and high susceptibility to minocycline highlight the need for more researches on these subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2019.0088","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T10:17:25Z","timestamp":1572257845000},"page":"429-433","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Synergistic Activities of Colistin Combinations with Meropenem, Sulbactam, Minocycline, Disodium Fosfomycin, or Vancomycin Against Different Clones of Carbapenem-Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    Strains"],"prefix":"10.1177","volume":"26","author":[{"given":"Ahmet","family":"Sertcelik","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology and Ankara Numune Training and Research Hospital, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmak","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esragul","family":"Akinci","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology and Ankara Numune Training and Research Hospital, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ipek","family":"Mumcuoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hurrem","family":"Bodur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology and Ankara Numune Training and Research Hospital, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/653120"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12363"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0267-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/529198"},{"key":"e_1_3_3_7_2","first-page":"pp","article-title":"Synergy testing: broth microdilution checkerboard and broth macrodilution methods","author":"Moody J.","year":"2010","unstructured":"Moody J. 2010. Synergy testing: broth microdilution checkerboard and broth macrodilution methods. In L.S. Garcia (ed.), Clinical microbiology procedures handbook. American Society for Microbiology Press,, Washington, pp. 5.16.1\u20135.16.23.","journal-title":"In L.S. Garcia (ed.), Clinical microbiology procedures handbook. American Society for Microbiology Press,"},{"key":"e_1_3_3_8_2","unstructured":"CLSI. 2017. Performance Standards for Antimicrobial Susceptibility Testing. 27th ed. CLSI Supplement M100 Wayne PA."},{"key":"e_1_3_3_9_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 2017. Breakpoint tables for interpretation of MICs and zone diameters Version 7.1. Available at www.eucast.org."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01230-13"},{"key":"e_1_3_3_11_2","first-page":"Doc14","article-title":"In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii","volume":"9","author":"Percin D.","year":"2014","unstructured":"Percin D., , Akyol S., , and Kalin G.. 2014. In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii. GMS Hyg. Infect. Control, 9:Doc14.","journal-title":"GMS Hyg. Infect. Control"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.5578\/mb.26289","article-title":"[Evaluation of the efficacy of colistin\/sulbactam combination on carbapenem-resistant Acinetobacter baumannii strains]","volume":"50","author":"\u00c7etinkol Y.","year":"2016","unstructured":"\u00c7etinkol Y., , Telli M., , Altun\u00e7eki\u00e7 Y\u0131ld\u0131r\u0131m A., and M.K. \u00c7alg\u0131n. 2016. [Evaluation of the efficacy of colistin\/sulbactam combination on carbapenem-resistant Acinetobacter baumannii strains]. Mikrobiyol. Bul. 50:460\u2013465.","journal-title":"Mikrobiyol. Bul"},{"key":"e_1_3_3_13_2","first-page":"890","article-title":"In vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against clinical isolates of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemases","volume":"42","author":"Santimaleeworagun W.","year":"2011","unstructured":"Santimaleeworagun W., , Wongpoowarak P., , Chayakul P., , Pattharachayakul S., , Tansakul P., , and Garey K.W.. 2011. In vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against clinical isolates of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemases. Southeast Asian J. Trop. Med. Public Health, 42:890\u2013900.","journal-title":"Southeast Asian J. Trop. Med. 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Agents Chemother"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10096-007-0456-4","article-title":"Antimicrobial susceptibility of multidrug-resistant Gram negative bacteria to fosfomycin","volume":"27","author":"Falagas M.E.","year":"2008","unstructured":"Falagas M.E., , Kanellopoulou M.D, , Karageorgopoulos D.E, , Dimopoulos G., , Rafailidis P.I, , Skarmoutsou N.D, , and Papafrangas E.A.. 2008. Antimicrobial susceptibility of multidrug-resistant Gram negative bacteria to fosfomycin. Eur. J. Clin. Microbiol. Infect. Dis. 27:439\u2013443.","journal-title":"Eur. J. Clin. Microbiol. Infect. 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Antimicrob. 12:24.","journal-title":"Clin. Microbiol. Antimicrob"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2334-11-109","article-title":"Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients","volume":"11","author":"Liang W.","year":"2011","unstructured":"Liang W., , Liu X.-F, , Huang J., , Zhu D.-M, , Li J., , and Zhang J.. 2011. Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients. BMC Infect. Dis. 11:109.","journal-title":"BMC Infect. 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