{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:34Z","timestamp":1777922974941,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>\n                    During 2014\u20132016, a total of 248 carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    (CARB-R Kp) were recovered in a Greek intensive care unit (ICU), the colistin resistance (COL-R) rates among CARB-R Kp from bloodstream infections (BSIs) were determined, and molecular characterization and the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    susceptibility of CARB-R+COL-R Kp to ceftazidime\/avibactam were performed. The majority of CARB-R Kp from BSIs (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200953) were OXA-48 (43.4%) and KPC (33.9%) producers, but no statistically significant differences were observed for the clinical characteristics of ICU patients affected by OXA-48 and other carbapenemase-producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    . CARB-R+COL-R Kp (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200928) represented 52.8% of 53 CARB-R Kp recovered from BSIs. The increase in the COL-R rates from 2014 to 2015 was mainly associated with the diffusion of extensively drug-resistant\n                    <jats:bold>(<\/jats:bold>\n                    XDR) OXA-48-co-producing CTX-M-15-like\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    , assigned to multilocus-sequence typing ST101, possessing alterations in the\n                    <jats:italic toggle=\"yes\">mgrB<\/jats:italic>\n                    loci. Ceftazidime\/avibactam was active against all OXA-48 and KPC producers. Thus, the spread of XDR Kp possessing different types of carbapenemases further complicates the infection control strategies for the management of XDR Kp, whereas ceftazidime\/avibactam may be a reasonable alternative to colistin for the treatment of XDR Kp in settings with low prevalence of metallo-\u03b2 lactamase-producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/mdr.2019.0090","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T14:27:40Z","timestamp":1565101660000},"page":"28-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Changing Characteristics and\n                    <i>In Vitro<\/i>\n                    Susceptibility to Ceftazidime\/Avibactam of Bloodstream Extensively Drug-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    from a Greek Intensive Care Unit"],"prefix":"10.1177","volume":"26","author":[{"given":"Angeliki","family":"Mavroidi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Katsiari","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Likousi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftheria","family":"Palla","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoi","family":"Roussou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charikleia","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Mathas","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Merkouri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia D.","family":"Platsouka","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Konstantopouleio-Patission, General Hospital of N. Ionias, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"e013634","DOI":"10.1136\/bmjopen-2016-013634","article-title":"EpideMiology and control measures of outBreaks due to Antibiotic-Resistant orGanisms in EurOpe (EMBARGO): a systematic review protocol","volume":"7","author":"Babu Rajendran N.","year":"2017","unstructured":"Babu Rajendran N., , Gladstone B.P., , Rodr\u00edguez-Ba\u00f1o J., , Sifakis F., , Voss A., , Carmeli Y., , Burkert F.R., , Gkolia P., , and Tacconelli E.. 2017. EpideMiology and control measures of outBreaks due to Antibiotic-Resistant orGanisms in EurOpe (EMBARGO): a systematic review protocol. 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