{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:25:34Z","timestamp":1791048334096,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Metallo-\u03b2-lactamase (MBL) producing bacteria constitute nowadays a serious global concern worldwide. The purpose of our present study was to characterize molecular features of MBL producing bacteria and to identify the existing clones in our area. Thirteen MBL-producing-\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    were detected in clinical samples from patients hospitalized in the Military hospital of Tunisia during 2017. The molecular research by polymerase chain reaction and sequencing of gene encoding MBL enzymes showed that only two types were identified in our study:\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM-1<\/jats:sub>\n                    genes detected, respectively, in eight and six isolates. An association between these two MBL genes (\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    +\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM-1<\/jats:sub>\n                    ) has been observed in one of our isolates. Other \u03b2-lactamase types (CTXM-15\/4 isolates; SHV\/2 isolates; OXA-48\/3 isolates) were detected in association with New Delhi metallo-beta-lactamase (NDM) and\/or Verona Integron-Mediated Metallo-\u03b2-lactamase (VIM) enzymes. Furthermore, these isolates were resistant to other antimicrobial agents, including gentamicin [\n                    <jats:italic toggle=\"yes\">aac<\/jats:italic>\n                    (3)-II\/11 isolates], tetracycline (\n                    <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                    B or\n                    <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                    A\/2 isolates), chloramphenicol (\n                    <jats:italic toggle=\"yes\">cml<\/jats:italic>\n                    A and\/or\n                    <jats:italic toggle=\"yes\">flo<\/jats:italic>\n                    R\/3 isolates), streptomycin (\n                    <jats:italic toggle=\"yes\">aad<\/jats:italic>\n                    A\/5 isolates), and sulfonamides (\n                    <jats:italic toggle=\"yes\">sul<\/jats:italic>\n                    1 or\n                    <jats:italic toggle=\"yes\">sul<\/jats:italic>\n                    2 or\n                    <jats:italic toggle=\"yes\">sul<\/jats:italic>\n                    3\/4isolates). The Multilocus Sequence Typing revealed 10 different Sequence types (ST) of which 7 novel ST: ST147 (3 isolates), ST101 (1 isolate), ST630 (1 isolate), ST3485 (1 isolate), ST3486 (1 isolate), ST3487 (1 isolate), ST3488 (1 isolate), ST3489 (1 isolate), ST3490 (1 isolate), ST3491 (2 isolates). Our study provides new data about MBL producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    in Tunisia. Thus, we report for the first time the coexpression of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM-1<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM-1<\/jats:sub>\n                    in our country and also we describe seven novel ST of MBL producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    in the world.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2019.0115","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T16:11:52Z","timestamp":1564503112000},"page":"1282-1286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["First Report of NDM and VIM Coproducing\n                    <i>Klebsiella pneumoniae<\/i>\n                    in Tunisia and Emergence of Novel Clones"],"prefix":"10.1177","volume":"25","author":[{"given":"Raoudha","family":"Dziri","sequence":"first","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Ayari","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouk","family":"Barguellil","sequence":"additional","affiliation":[{"name":"Service of Microbiology, Military Hospital of Tunis HMPIT, Tunis, Tunisia."},{"name":"Department of Microbiology, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadda-Imen","family":"Ouzari","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Selim","family":"El Asli","sequence":"additional","affiliation":[{"name":"Service of Microbiology, Military Hospital of Tunis HMPIT, Tunis, Tunisia."},{"name":"Department of Microbiology, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naouel","family":"Klibi","sequence":"additional","affiliation":[{"name":"Laboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06796.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2174\/1389450116666151001105622","article-title":"B1-metallo-beta-lactamases: where do we stand? 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