{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:44Z","timestamp":1777922984498,"version":"3.51.4"},"reference-count":93,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      is a major opportunistic pathogen frequently associated with nosocomial infections, and often poses a major threat to immunocompromised patients. In our previous study, two\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      (K36 and B13), which displayed resistance to almost all major antibiotics, including colistin, were isolated. Both isolates were not associated with infection and isolated from the stools of two preterm neonates admitted to the neonatal intensive care unit (NICU) during their first week of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, whole genome sequencing was performed on these two clinical multidrug resistant\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      . We aimed to determine the genetic factors that underline the antibiotic-resistance phenotypes of these isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The strains harbored\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>SHV-27<\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>SHV-71<\/jats:sub>\n                      , and\n                      <jats:italic toggle=\"yes\">oqxAB<\/jats:italic>\n                      genes conferring resistance to cephalosporins, carbapenems, and fluoroquinolones, respectively, but not harboring any known plasmid-borne colistin resistance determinants such as\n                      <jats:italic toggle=\"yes\">mcr-1<\/jats:italic>\n                      . However, genome analysis discovered interruption of\n                      <jats:italic toggle=\"yes\">mgrB<\/jats:italic>\n                      gene by insertion sequences gaining insight into the development of colistin resistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The observed finding that points to a scenario of potential gut-associated resistance genes to Gram negative (\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      ) host in the NICU environment warrants attention and further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2019.0199","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:42:26Z","timestamp":1569238946000},"page":"190-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Genomic Insights into Two Colistin-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    Strains Isolated from the Stool of Preterm Neonate During the First Week of Life"],"prefix":"10.1177","volume":"26","author":[{"given":"Polly Soo Xi","family":"Yap","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azanna","family":"Ahmad Kamar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Wie","family":"Chong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Monash University, Jalan Lagoon Selatan, Selangor, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Tein","family":"Ngoi","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy Shuan Ju","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"531","article-title":"Cost of antimicrobial treatment of patients infected with multidrug-resistant organisms in the Intensive Care Unit","volume":"71","author":"Cartaxo Salgado F.X.","year":"2011","unstructured":"Cartaxo Salgado F.X., , Carneiro Goncalves J., , Monteiro De Souza C., , Barbosa Da Silva N., , Gavilanes Sanchez T.E, , and Gomes de Oliveira Karnikowski M.. 2011. 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