{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:11:18Z","timestamp":1788999078798,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>\n                    Aspirin is one of the most commonly used nonsteroidal anti-inflammatory drugs. Various potential pharmacological effects of aspirin, such as anticancer, antibacterial activity, and prolonging life expectancy have been discovered. However, the mechanism of aspirin is not fully elucidated. Herein, the effects of aspirin on fatty acid metabolism in yeast cell model\n                    <jats:italic toggle=\"yes\">Saccharomyces cerevisiae<\/jats:italic>\n                    were studied. The results showed that aspirin can induce lipid accumulation and reduce the unsaturated fat index in cells. The assessment of cell membrane integrity demonstrated that aspirin caused damage to the cell membrane. These effects of aspirin were attributed to the alterations of the expression of\n                    <jats:italic toggle=\"yes\">DCI1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">OLE1<\/jats:italic>\n                    . Similarly, aspirin was able to cause lipid accumulation and damage to the cell membrane by interfering with the expression of\n                    <jats:italic toggle=\"yes\">OLE1<\/jats:italic>\n                    in\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    . These findings are expected to improve current understanding of the mode of action of aspirin and provide a novel strategy for antifungal drug design.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" orientation=\"portrait\" position=\"float\" xlink:href=\"10.1089_mdr.2019.0200-fig6.tif\"\/>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2019.0200","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T14:15:11Z","timestamp":1581516911000},"page":"857-868","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Aspirin Causes Lipid Accumulation and Damage to Cell Membrane by Regulating\n                    <i>DCI1<\/i>\n                    \/\n                    <i>OLE1<\/i>\n                    in\n                    <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1177","volume":"26","author":[{"given":"Pan","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongjia","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, the Chinese Academy of Sciences, Xining, Qinghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Peng","sequence":"additional","affiliation":[{"name":"Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, the Chinese Academy of Sciences, Xining, Qinghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Lab of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1206"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70545-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/nrclinonc.2012.216","article-title":"Biological markers: potential biomarker for aspirin use in colorectal cancer therapy","volume":"10","author":"Langley R.E.","year":"2013","unstructured":"Langley R.E., , and Rothwell P.M.. 2013. 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