{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:29:56Z","timestamp":1777922996867,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"\n Objectives:<\/jats:title>\n \n Solithromycin is a fluoroketolide that is considered to be a noninducing antibiotic for macrolide\u2013lincosamide\u2013streptogramin B resistance mediated by\n erm<\/jats:italic>\n genes. The exact activity of solithromycin to induce\n erm<\/jats:italic>\n gene expression remains to be determined.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n The potential of solithromycin to induce\n erm<\/jats:italic>\n (A),\n erm<\/jats:italic>\n (C), and\n erm<\/jats:italic>\n (B) gene expression was examined using a\n lacZ<\/jats:italic>\n reporter assay, double-disk diffusion test, and determination of the minimal inhibitory concentration after incubation with subinhibitory concentration of different antibiotics.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Neither solithromycin nor the ketolides telithromycin and cethromycin induced\n erm<\/jats:italic>\n (A) or\n erm<\/jats:italic>\n (C) gene expression. However, solithromycin could significantly induce\n erm<\/jats:italic>\n (B) gene expression at levels greater than that seen for cethromycin and clindamycin, but less than that for erythromycin, rokitamycin, and telithromycin.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Solithromycin does not induce\n erm<\/jats:italic>\n (A) and\n erm<\/jats:italic>\n (C) gene expression, but does induce\n erm<\/jats:italic>\n (B) gene expression, although to a weaker extent than that seen for macrolides.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/mdr.2019.0293","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T11:50:46Z","timestamp":1585309846000},"page":"1046-1049","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Solithromycin Can Specifically Induce Macrolide\u2013Lincosamide\u2013Streptogramin B Resistance"],"prefix":"10.1177","volume":"26","author":[{"given":"Yu-Hong","family":"Min","sequence":"first","affiliation":[{"name":"College of Medical Science, Daegu Haany University, Gyeongsan, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00185.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.1.85"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.05.001"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01266-07"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01994-13"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S119545"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.08.035"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04089.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.10.5892-5900.1990"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.150.2.804-814.1982"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01376-07"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3415-3420.2003"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2562"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00524-16"},{"key":"e_1_3_4_16_2","unstructured":"Clinical and Laboratory Standards Institute. 2015. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically. 10th ed. Approved Standard M07-A10. CLSI Wayne PA."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.1-12.2001"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr626"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2019.0293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2019.0293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2019.0293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:36:27Z","timestamp":1777667787000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2019.0293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["10.1089\/mdr.2019.0293"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2019.0293","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}