{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:14:38Z","timestamp":1792696478088,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The prevalence of extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) is now disseminated worldwide. This study aims to describe the prevalence of ESBL and CPE fecal carriage in colorectal cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All patients admitted to the oncology service of Amizour hospital (Algeria) for colorectal cancer chemotherapy from March to May 2019 were screened for ESBL-E or CPE fecal carriage. After culturing on chromogenic media, the presumptive colonies were identified by mass spectroscopy. Antibiotic susceptibility testing was performed according to the European Committee on Antimicrobial Susceptibility Testing. The \u03b2-lactamases encoding genes and plasmid-mediated quinolone-resistant genes were screened by PCR and sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      ESBL-E strains were recovered from rectal swabs in 6 patients (14.3%) and only 1 patient (2.4%) was found a carrier for OXA-48-producing\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      . The most frequently encountered species among ESBL-E was\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20095), followed by\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091). PCR and sequencing showed that four isolates harbored the\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-15<\/jats:sub>\n                      gene and two strains harbored the\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-14<\/jats:sub>\n                      gene. Also, one strain of\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      was found to harbor both\n                      <jats:italic toggle=\"yes\">qepA<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">qnrS<\/jats:italic>\n                      genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlighted the fecal carriage of ESBL-E and OXA-48-producing Enterobacterales strains in colorectal cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2019.0350","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T09:57:41Z","timestamp":1584439061000},"page":"1383-1389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Fecal Carriage of Extended-Spectrum \u03b2-Lactamase and Carbapenemase-Producing Enterobacterales Strains in Patients with Colorectal Cancer in the Oncology Unit of Amizour Hospital, Algeria: A Prospective Cohort Study"],"prefix":"10.1177","volume":"26","author":[{"given":"Abdelaziz","family":"Touati","sequence":"first","affiliation":[{"name":"Laboratoire d'Ecologie microbienne, FSNV, Universit\u00e9 de Bejaia, Bejaia, Alg\u00e9rie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Talbi","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie microbienne, FSNV, Universit\u00e9 de Bejaia, Bejaia, Alg\u00e9rie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Mairi","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie microbienne, FSNV, Universit\u00e9 de Bejaia, Bejaia, Alg\u00e9rie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaziz","family":"Messis","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordj Bou Arreridj, Bordj Bou Arreridj, Alg\u00e9rie."},{"name":"Laboratoire de G\u00e9nie Biologique des Cancers, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bejaia, Bejaia, Alg\u00e9rie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Adjebli","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie microbienne, FSNV, Universit\u00e9 de Bejaia, Bejaia, Alg\u00e9rie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Louardiane","sequence":"additional","affiliation":[{"name":"Service d'oncologie, h\u00f4pital Ben Merrad El Meki Amizour, Bejaia, Alg\u00e9rie."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Philippe","family":"Lavigne","sequence":"additional","affiliation":[{"name":"U1047, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Montpellier, France."},{"name":"Service de Microbiologie et Hygi\u00e8ne Hospitali\u00e8re, CHU N\u00eemes, N\u00eemes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"The Global Cancer Observatory. 2018. https:\/\/gco.iarc.fr\/today."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2019.1645007"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks065"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm318"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.682"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.08.021"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13302"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13113"},{"key":"e_1_3_4_10_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 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