{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:05Z","timestamp":1787008265859,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:italic toggle=\"yes\">Staphylococcus haemolyticus<\/jats:italic>\n                      is considered as a part of normal skin flora, infections associated with them are increasing. Irrespective of the low virulence profile it poses a severe threat to patients with indwelling devices due to its multidrug-resistant nature. The aim of this study was to determine antibiotic resistance patterns and to detect the genes responsible in clinical isolates of\n                      <jats:italic toggle=\"yes\">S. haemolyticus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All the 356\n                      <jats:italic toggle=\"yes\">S. haemolyticus<\/jats:italic>\n                      isolates were susceptible to glycopeptides. 91.3% were resistant to cefoxitin, 85.4% to erythromycin, 57.3% to co-trimoxazole, 52.8% to clindamycin, whereas only 3.7% of isolates were resistant to linezolid. Tetracycline resistance was found in 16.6% of isolates with\n                      <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                      K as the major genetic determinant. Most of the cefoxitin-resistant isolates carried\n                      <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                      A gene (99.4%), whereas\n                      <jats:italic toggle=\"yes\">dfr<\/jats:italic>\n                      G gene was found only in 57.3% of co-trimoxazole-resistant isolates. Macrolides resistance was seen in 85.4% of isolates with cMLS\n                      <jats:sub>B<\/jats:sub>\n                      (constitutive macrolide, lincosamide, and streptogramin B) (42.5%) as the major phenotype with\n                      <jats:italic toggle=\"yes\">erm<\/jats:italic>\n                      C and\n                      <jats:italic toggle=\"yes\">msr<\/jats:italic>\n                      AB genes as the predominant genetic determinants. Among linezolid-resistant isolates all except one showed higher minimum inhibitory concentration (MIC) (&gt;256\u2009\u03bcg\/mL) with chloramphenicol\u2013florfenicol resistance (\n                      <jats:italic toggle=\"yes\">cfr)<\/jats:italic>\n                      gene as the genetic determinant, whereas one isolate had a lower MIC (16\u2009\u03bcg\/mL) and was negative for\n                      <jats:italic toggle=\"yes\">cfr<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Emerging resistance to linezolid is a cause for concern. Strategies to prevent the spread of antibiotic resistance require continuous surveillance of these multidrug-resistant strains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2019.0395","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T15:43:17Z","timestamp":1584632597000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Prevalence and Molecular Determinants of Antimicrobial Resistance in Clinical Isolates of\n                    <i>Staphylococcus haemolyticus<\/i>\n                    from India"],"prefix":"10.1177","volume":"27","author":[{"given":"Meerabai","family":"Manoharan","sequence":"first","affiliation":[{"name":"Department of Microbiology, JIPMER, Pondicherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujatha","family":"Sistla","sequence":"additional","affiliation":[{"name":"Department of Microbiology, JIPMER, Pondicherry, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, PGIMER, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"e0156653","DOI":"10.1371\/journal.pone.0156653","article-title":"Impact of insertion sequences and recombination on the population structure of Staphylococcus haemolyticus","volume":"11","author":"Bouchami O.","year":"2016","unstructured":"Bouchami O., , de Lencastre H., , and Miragaia M.. 2016. 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