{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:30:15Z","timestamp":1777923015733,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    The aim of this study was to evaluate the antibacterial properties of methylsulfonylmethane (MSM) on vancomycin-resistant\n                    <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                    (VRE). Bacterial proliferation was measured spectrophotometrically during growth in brain heart infusion broth with 0%, 3%, 5%, 7%, 10%, 12%, and 16% MSM. To assess the mechanism of inhibition, VRE was grown overnight with 0\u201316% MSM and enumerated on unmedicated and medicated (3\u201316% MSM) brain heart infusion agar (BHIA). Viability studies were performed to evaluate the impact of 10\u201316% MSM on VRE over 7 days. Absorbance data indicated a dose-dependent inhibition from 0% to 7% MSM and no increase in optical density in 10\u201316% MSM. VRE enumerated on unmedicated BHIA from overnight cultures with 10\u201316% MSM partially recovered. No growth was observed when BHIA contained 10\u201316% MSM. There was little effect on VRE growth in 10% MSM over 7 days. VRE displayed a population rebound on day 6 when exposed to 12% MSM, and elimination by day 6 in 16% MSM. Regrowth after MSM removal may be indicative of a bacteriostatic mechanism of inhibition. Cell elimination in 16% MSM suggests inhibition of an essential metabolic function from which the bacterium could not recover.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2019.0454","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T22:11:36Z","timestamp":1591827096000},"page":"13-17","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Methylsulfonylmethane Exhibits Bacteriostatic Inhibition of Vancomycin-Resistant\n                    <i>Enterococcus faecium<\/i>\n                    ,\n                    <i>In Vitro<\/i>"],"prefix":"10.1177","volume":"27","author":[{"given":"Toni L.","family":"Poole","sequence":"first","affiliation":[{"name":"USDA, Agricultural Research Service, Plains Agricultural Research Center, College Station, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Bergstrom Nutrition, Vancouver, Washington, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Genovese","sequence":"additional","affiliation":[{"name":"USDA, Agricultural Research Service, Plains Agricultural Research Center, College Station, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Nisbet","sequence":"additional","affiliation":[{"name":"USDA, Agricultural Research Service, Plains Agricultural Research Center, College Station, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.GPP3-0053-2018","article-title":"Pathogenicity of Enterococci","volume":"7","author":"Fiore E.","year":"2019","unstructured":"Fiore E., , Van Tyne D., , and Gilmore M.S.. 2019. 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