{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:47:02Z","timestamp":1787240822123,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Thirty-nine carbapenem-resistant hypervirulent\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    (CR-hvKP) isolates collected from a Chinese tertiary hospital were used in the characterization of the prevalence of 16S rRNA methylase genes. In total, 66.7% (26\/39) of the CR-hvKP isolates were found to carry 16S rRNA methylase genes. The most frequently detected 16S rRNA methylase gene was\n                    <jats:italic toggle=\"yes\">armA<\/jats:italic>\n                    (11\/26, 42.3%), followed by\n                    <jats:italic toggle=\"yes\">rmtB<\/jats:italic>\n                    (8\/26, 30.8%), and coexistence of both\n                    <jats:italic toggle=\"yes\">armA<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">rmtB<\/jats:italic>\n                    (7\/26, 26.9%). All the clinical isolates were found to carry at least one carbapenemase gene, with\n                    <jats:italic toggle=\"yes\">blaKPC-2<\/jats:italic>\n                    (79.5%, 31\/39),\n                    <jats:italic toggle=\"yes\">blaNDM-1<\/jats:italic>\n                    (10.3%, 4\/39), and cocarrying\n                    <jats:italic toggle=\"yes\">blaKPC-2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">blaNDM-1<\/jats:italic>\n                    (10.3%, 4\/39). A total of 89.7% (35\/39) isolates carried extended-spectrum \u03b2-lactamase (ESBL) genes, including 61.5% (24\/39)\n                    <jats:italic toggle=\"yes\">blaSHV-1<\/jats:italic>\n                    , 71.8% (28\/39)\n                    <jats:italic toggle=\"yes\">blaTEM-1<\/jats:italic>\n                    , and 89.7% (35\/39)\n                    <jats:italic toggle=\"yes\">blaCTX-M-14<\/jats:italic>\n                    . All except four isolates (89.7%, 35\/39) harbored quinolone resistance genes, with\n                    <jats:italic toggle=\"yes\">qnrS<\/jats:italic>\n                    (82.1%, 32\/39),\n                    <jats:italic toggle=\"yes\">aac(6\u2019)-Ib-cr<\/jats:italic>\n                    (79.5%, 31\/39), and\n                    <jats:italic toggle=\"yes\">qnrB<\/jats:italic>\n                    (2.6%, 1\/39). Twenty-six hvKP strains in this study were first reported to cocarry carbapenemase genes, ESBL genes, quinolone resistance genes, and 16S rRNA methylase genes simultaneously. Multilocus sequence typing (MLST) analysis assigned the 39 CR-hvKP isolates into 4 sequence types (STs), with ST11 encompassing 79.5% of the strains. Pulsed field gel electrophoresis (PFGE) typing showed that strains closely related by MLST clustered in major PFGE clusters, of which cluster A accounts for 31 ST11 isolates. Cumulatively, 16S rRNA methylase genes are highly prevalent in CR-hvKP clinical isolates especially for ST11; it is, therefore, critical to continuously monitor the epidemiology of these 16S rRNA methylase-producing CR-hvKP while simultaneously minimizing potential risks from aminoglycoside-resistant CR-hvKP.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2019.0482","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T22:53:43Z","timestamp":1589928823000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["High Prevalence of 16s rRNA Methylase Genes Among Carbapenem-Resistant Hypervirulent\n                    <i>Klebsiella pneumoniae<\/i>\n                    Isolates in a Chinese Tertiary Hospital"],"prefix":"10.1177","volume":"27","author":[{"given":"Wenjian","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"De Wang","sequence":"additional","affiliation":[{"name":"National Centre for Infectious Diseases, Infectious Disease Research Laboratory, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-ling","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, The First Affiliated Hospital of Nanchang University, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, The First Affiliated Hospital of Nanchang University, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, The First Affiliated Hospital of Nanchang University, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OonTek","family":"Ng","sequence":"additional","affiliation":[{"name":"National Centre for Infectious Diseases, Infectious Disease Research Laboratory, Singapore, Singapore."},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00078-15"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"e01775","DOI":"10.1128\/AAC.01775-18","article-title":"An IncR plasmid harbored by a hypervirulent carbapenem-resistant Klebsiella pneumoniae strain possesses five tandem repeats of the blaKPC-2::NTEKPC-Id fragment","volume":"63","author":"Dong N.","year":"2019","unstructured":"Dong N., , Liu L., , Zhang R., , Chen K., , M. 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