{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:53:40Z","timestamp":1779224020944,"version":"3.51.4"},"reference-count":83,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    is an opportunistic bacterial pathogen most commonly associated with nosocomial infections, especially in intensive care unit (ICU) patients. Routine surveillance cultures for carbapenemase-producing Enterobacteriaceae have become a common practice for hospital infection prevention. The objective of this study was to investigate the genetic relatedness of carbapenem-resistant\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    carrying\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    gene across multilocus sequence typing (MLST) scheme. Surveillance rectal swabs from 4,463 ICU patients admitted to the Rio de Janeiro hospital (March 2016\u20132017) were screened on CHROMagar mSuperCARBA. Of these, 631 isolates were subjected to VITEK 2 system for phenotypic microbial identification and antibiotic susceptibility testing. Out of 631 isolates, 108 were identified as\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    , 103 of which were confirmed by PCR of 16S\u201323S rDNA internal transcribed spacer (ITS). Eleven\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    -positive isolates were subsequently screened for\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>KPC<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>BKC<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>IMP<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>SPM<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    , and\n                    <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                    -1-8 genes. Twenty-seven percent (3\/11) revealed co-occurrence with KPC, OXA-48, and VIM, 46% (5\/11) with KPC and VIM, and 18% (2\/11) with VIM type. No strains harbored the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>BKC<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>SPM<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>IMP<\/jats:sub>\n                    , and\n                    <jats:italic toggle=\"yes\">mcr<\/jats:italic>\n                    -1 to 8 resistance genes. All 11 isolates were resistant to \u03b2-lactams, ciprofloxacin 90%, tigecycline 82%, gentamicin 73%, and amikacin 18%, and were classified as multidrug resistant (MDR), extensively drug resistant (XDR), and pandrug resistant (PDR). Molecular epidemiology data based on MLST revealed 11 different STs, 8 of which were novel and 3 were previously described. Six out of the eight new STs were associated with MDR and PDR strains and two clonal complexes were reported, including CC258 and CC15. The coexistence of NDM-producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    and other carbapenemase has been frequently described worldwide. Moreover, we report for the first time\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    co-harboring up to four carbapenemases from active surveillance cultures.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2019.0483","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T17:05:27Z","timestamp":1586797527000},"page":"1219-1226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic Relatedness of NDM-Producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    Co-Occurring VIM, KPC, and OXA-48 Enzymes from Surveillance Cultures from an Intensive Care Unit"],"prefix":"10.1177","volume":"26","author":[{"given":"Claudia","family":"Flores","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Bianco","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivano","family":"de Filippis","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysa Mandetta","family":"Clementino","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia Maria C.P.A.","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-018-1475-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2019.0061"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2147\/IDR.S170233","article-title":"Carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa: characterization of carbapenemase genes and E-test evaluation of colistin-based combinations","volume":"11","author":"Ramadan R.A.","year":"2018","unstructured":"Ramadan R.A., , Gebriel M.G, , Kadry H.M, , and Mosallem A.. 2018. Carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa: characterization of carbapenemase genes and E-test evaluation of colistin-based combinations. Infect. Drug Resist. 11:1261\u20131269.","journal-title":"Infect. Drug Resist"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ajg.2019.01.002","article-title":"Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt","volume":"20","author":"Ghaith D.M.","year":"2019","unstructured":"Ghaith D.M., , Mohamed Z.K, , Farahat M.G, , Aboulkasem Shahin W., , and Mohamed H.O.. 2019. Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt. Arab J. Gastroenterol. 20:19\u201322.","journal-title":"Arab J. 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