{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:36:27Z","timestamp":1790958987214,"version":"4.1.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>\n                    This study was performed to elucidate genetic relatedness and molecular resistance mechanisms of AmpC-producing multidrug-resistant\n                    <jats:italic toggle=\"yes\">Proteus mirabilis<\/jats:italic>\n                    isolates in University Hospital of Split (UHS), and define efficient antibiotics\n                    <jats:italic toggle=\"yes\">in vitro.<\/jats:italic>\n                    A total of 100 nonrepeated, consecutive, amoxicillin\/clavulanate- and cefoxitin-resistant\n                    <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                    isolates were collected, mostly from urine (44%) and skin and soft-tissue samples (30%). They were all positive in cefoxitin Hodge test and negative for extended spectrum beta-lactamase production. Pulsed field gel electrophoresis identified four clusters and two singletons, with 79% of isolates in dominant cluster. Molecular characterization and\n                    <jats:italic toggle=\"yes\">I-C<\/jats:italic>\n                    euI analysis of representatives revealed\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-16<\/jats:sub>\n                    gene located on chromosome, and insertion element IS\n                    <jats:italic toggle=\"yes\">Ecp1<\/jats:italic>\n                    positioned 110 pb upstream of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-16<\/jats:sub>\n                    starting codon. They also harbored\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    , except one with\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-2<\/jats:sub>\n                    . They were all resistant to trimethoprim-sulfamethoxazole, all but one to quinolones, and 81% to all aminoglycosides, while 77% were susceptible (S) and 22% intermediate (I) to piperacillin\/tazobactam, and 4% were S and 68% I to cefepime. Only 15% were S to ceftolozane\/tazobactam. Meropenem, ertapenem, ceftazidime\/avibactam, temocillin, and fosfomycin were 100% efficient\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . This is the first report of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-16<\/jats:sub>\n                    gene in\n                    <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                    from hospital samples in Croatia. The findings are in accordance with Italian and Greek reports. The clonal nature of outbreak suggests the high potential of clonal spread. Alternative agents should be considered to spare carbapenem usage.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0002","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T22:53:38Z","timestamp":1589928818000},"page":"162-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Molecular Characterization of \u03b2-Lactam Resistance and Antimicrobial Susceptibility to Possible Therapeutic Options of AmpC-Producing Multidrug-Resistant\n                    <i>Proteus mirabilis<\/i>\n                    in a University Hospital of Split, Croatia"],"prefix":"10.1177","volume":"27","author":[{"given":"Zana","family":"Rubic","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital of Split, Split, Croatia."},{"name":"University of Split School of Medicine, Split, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvija","family":"Soprek","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevic,\u201d Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Jelic","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevic,\u201d Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital of Split, Split, Croatia."},{"name":"University of Split School of Medicine, Split, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Goic-Barisic","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital of Split, Split, Croatia."},{"name":"University of Split School of Medicine, Split, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Radic","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital of Split, Split, Croatia."},{"name":"University of Split School of Medicine, Split, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjana","family":"Tambic-Andrasevic","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital for Infectious Diseases \u201cDr. Fran Mihaljevic,\u201d Zagreb, Croatia."},{"name":"University of Zagreb School of Dental Medicine, Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Tonkic","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, University Hospital of Split, Split, Croatia."},{"name":"University of Split School of Medicine, Split, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00036-08"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1110"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf193"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4136-4143.2004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.618-624.2006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00043-08"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.09.007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02864.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01872-09"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01736-10"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01450-13"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00828-15"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-006-0483-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.2938-2945.2003"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"e0120688","DOI":"10.1371\/journal.pone.0120688","article-title":"Microbiological screening is necessary to distinguish carriers of plasmid-mediated AmpC beta-lactamase-producing Enterobacteriaceae and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae because of clinical similarity","volume":"24","author":"Conen A.","year":"2015","unstructured":"Conen A., , Frei R., , Adler H., , Dangel M., , Fux C.A, , and Widmer A.F.. 2015. 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