{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:24:46Z","timestamp":1783142686341,"version":"3.54.6"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To determine the epidemiology, risk factors, and prognosis of extended-spectrum beta-lactamase (ESBL)-producing\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      bloodstream infections (BSIs) among hematology malignancy (HM) patients in China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      From January 2010 to June 2018, we retrospectively collected and analyzed the 449 HM patients with\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      BSIs from three leading hospitals in Hunan Province, China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two hundred four (45.4%) patients harbored ESBL-producing bacteremia. The proportion of ESBL-producing bacteremia increased significantly with the growth of the year, with a ratio of 34.47% in 2010\u20132014 to 54.7% in 2015\u20132018. Comparing with non-ESBL groups in HM patients, central venous catheter (odds ratio [OR] 1.717,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.009), previous antibiotic exposure (OR 1.559,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.035), and\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      (OR 2.561,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\u2264\u20090.001) among ESBL groups were independent risk factors. No significant differences in 30-day mortality were tested in patients with BSI caused by ESBL-producing or non-ESBL-producing\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      (17.1% vs. 16.7%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090. 893). The proportion of carbapenem used within 72 hours after the onset of bacteremia in two groups was high, which was routinely used as \u201clast-resort drugs\u201d in Gram-negative bacterial infections. Risk factors associated with 30-day mortality in HM patients with\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      bacteremia were myelodysplastic syndrome, incomplete remission of the disease, Multinational Association of Supportive Care in Cancer score &lt;21, Pitt bacteremia score \u22654, Charlson comorbidity score &gt;3, catheter insertion, use of vasopressors, and inappropriate antibiotics within 72 hours of BSI onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of this study may provide some references for the whole process management of HM patients with BSIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2020.0033","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T17:37:39Z","timestamp":1606239459000},"page":"800-808","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Epidemiology, Risk Factors, and Clinical Outcomes of Bloodstream Infection due to Extended-Spectrum Beta-Lactamase-Producing\n                    <i>Escherichia coli<\/i>\n                    and\n                    <i>Klebsiella pneumoniae<\/i>\n                    in Hematologic Malignancy: A Retrospective Study from Central South China"],"prefix":"10.1177","volume":"27","author":[{"given":"Ting","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","unstructured":"Pana Z.D. and Zaoutis T.. 2018. 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