{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:17:23Z","timestamp":1785417443798,"version":"3.56.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    Recurrent vulvovaginal candidiasis (RVVC) is caused by\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    spp., a vaginal colonizer. Despite the clinical importance of RVVC, little is known regarding the characteristics of the disease in Portugal. Thirty-six clinical cases were analyzed, comprising 93 yeast vulvovaginal isolates obtained from women attending a gynecologic consultation at a private clinic. Of these, 18 women were diagnosed with RVVC, while other 18 women had a sporadic episode of infection (nonrecurrent vulvovaginal candidiasis [NR-VVC]). Species identification was performed with CHROMagar chromogenic medium and by analysis of biochemical profiles. In addition, antifungal susceptibility testing for two azole compounds was performed by broth microdilution. We found that\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    was isolated from both NR-VVC and RVVC cases, being highly predominant;\n                    <jats:italic toggle=\"yes\">C. glabrata<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n                    were also isolated. Resistance to at least one antifungal was detected in up to 65% of the isolates, and resistance to both antifungals reached a frequency of 25%. Moreover, azole-resistant isolates were distributed among all species identified. We conclude that in the studied group of patients,\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    is in fact the major player both in NR-VVC and in RVVC,\n                    <jats:italic toggle=\"yes\">C. glabrata<\/jats:italic>\n                    being more frequently associated with recurrence (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In addition, we found a high proportion of azole-resistant strains.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0139","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T11:06:16Z","timestamp":1614596776000},"page":"1087-1095","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Species Distribution and Antifungal Susceptibility Profiles of Isolates from Women with Nonrecurrent and Recurrent Vulvovaginal Candidiasis"],"prefix":"10.1177","volume":"27","author":[{"given":"Joana","family":"Rolo","sequence":"first","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Faria-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"FMUMN\u2014Faculty of Medicine, University of Mandume ya Ndemufayo, Lubango, Angola."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Barata","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Sofia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gaspar","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Labfit-HPRD\u2014Health Products Research and Development Lda, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Saraiva","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Center of Mathematics and Applications, University of Beira Interior, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"FMUMN\u2014Faculty of Medicine, University of Mandume ya Ndemufayo, Lubango, Angola."},{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Martinez-de-Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Costa-de-Oliveira","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal."},{"name":"Center for Research in Health Technologies and Information Systems (CINTESIS), Porto, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal."},{"name":"Labfit-HPRD\u2014Health Products Research and Development Lda, Covilh\u00e3, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.mpmed.2010.02.001","article-title":"Genital candidiasis","volume":"38","author":"Sobel, J.D","year":"2010","unstructured":"Sobel, J.D. 2010. 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