{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:07:39Z","timestamp":1792001259279,"version":"4.4.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>\n                    The spread of resistance to vancomycin and other last-resort drugs in\n                    <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                    spp. remains of concern. In Italy, surveillance data for enterococcal bloodstream isolates in humans are scant. The aim of our study was to assess the incidence trends of bacteremias due to\n                    <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                    species and their prevalence trends of antimicrobial resistance. We retrospectively included all consecutive not-duplicate\n                    <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                    species isolated from blood cultures, in patients from 11 Italian hospitals (2011\u20132017). Incidence was defined as the number of isolates per 10,000 patient-days, while resistance prevalence was defined as the number of resistant strains divided by the number of tested strains. We included 4,858 isolates (59%, 36%, and 5% due to\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    , and other\n                    <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                    spp., respectively). Over the study period, the incidence of bacteremias due to\n                    <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                    (incidence rate ratio [IRR]: 1.02, 95% confidence interval [CI]: 1.00\u20131.04,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.008) and\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    increased (IRR: 1.03, 95% CI: 1.01\u20131.05,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) alongside with the whole enterococcal bacteremias trend (IRR: 1.02, 95% CIs: 1.01\u20131.04,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002). A progressive increase in vancomycin-resistant\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    (VREfm) bacteremias was observed. Resistance to tigecycline and linezolid was rarely reported. The incidence of enterococcal bloodstream isolates is increasing in Italy, together with the prevalence of VREfm. Resistance to linezolid, a cornerstone drug used in the treatment of VRE bloodstream infection, remains negligible.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0147","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T11:23:55Z","timestamp":1600428235000},"page":"529-535","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Trends in the Incidence and Antibiotic Resistance of Enterococcal Bloodstream Isolates: A 7-Year Retrospective Multicenter Epidemiological Study in Italy"],"prefix":"10.1177","volume":"27","author":[{"given":"Jacopo","family":"Monticelli","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Roberto","family":"Giacobbe","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive, Ospedale Policlinico San Martino\u2014IRCCS, Genoa, Italy."},{"name":"Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardino","family":"Amato","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera \u201cA. Cardarelli,\u201d Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Maria","family":"Antonello","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Barone","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Valtellina e Valchiavenna, Ospedale di Sondrio, Sondrio, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Brachelente","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Perugia \u201cSanta Maria della Misericordia,\u201d Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Busetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Carcione","sequence":"additional","affiliation":[{"name":"IRCCS Centro Cardiologico Monzino, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Carretto","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Reggio Emilia\u2014\u201cArcispedale Santa Maria Nuova,\u201d Reggio Emilia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giulio","family":"Conaldi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Degl'Innocenti","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera \u201cA. Cardarelli,\u201d Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Del Puente","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive, Ospedale Policlinico San Martino\u2014IRCCS, Genoa, Italy."},{"name":"Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Knezevich","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Luzzaro","sequence":"additional","affiliation":[{"name":"ASST Lecco-Ospedale \u201cA. Manzoni,\u201d Lecco, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Mainelli","sequence":"additional","affiliation":[{"name":"ASL Roma 1\u2014Presidio Ospedaliero San Filippo Neri, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marchese","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Microbiologia, Ospedale Policlinico San Martino\u2014IRCCS, Genoa, Italy."},{"name":"Department of Surgical and Integrated Diagnostic Sciences (DISC), University of Genoa, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Meledandri","sequence":"additional","affiliation":[{"name":"ASL Roma 1\u2014Presidio Ospedaliero San Filippo Neri, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Mencacci","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Perugia \u201cSanta Maria della Misericordia,\u201d Perugia, Italy."},{"name":"Department of Medicine, University of Perugia, Perugia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Miragliotta","sequence":"additional","affiliation":[{"name":"AOU Policlinico di Bari, Bari, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Monaco","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Morabito","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Valtellina e Valchiavenna, Ospedale di Sondrio, Sondrio, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Mosca","sequence":"additional","affiliation":[{"name":"AOU Policlinico di Bari, Bari, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Nardini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Reggio Emilia\u2014\u201cArcispedale Santa Maria Nuova,\u201d Reggio Emilia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Principe","sequence":"additional","affiliation":[{"name":"ASST Lecco-Ospedale \u201cA. Manzoni,\u201d Lecco, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Riggio","sequence":"additional","affiliation":[{"name":"IRCCS Centro Cardiologico Monzino, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Viaggi","sequence":"additional","affiliation":[{"name":"ASST Lecco-Ospedale \u201cA. 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