{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:30:44Z","timestamp":1777923044779,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The treatment of multidrug-resistant tuberculosis (MDR-TB) is a challenge to be overcome. The increase of resistant isolates associated with serious side effects during therapy leads to the search for substances that have anti-TB activity, which make treatment less toxic, and also act in the macrophage acidic environment promoted by the infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to investigate lapachol and \u03b2-lapachone activities in combination with other drugs against\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      at neutral and acidic pH and its cytotoxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Inhibitory and bactericidal activities against\n                      <jats:italic toggle=\"yes\">M. tuberculosis<\/jats:italic>\n                      and clinical isolates were determined. Drug combination and cytotoxicity assay were carried out using standard TB drugs and\/or\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      -acetylcysteine (NAC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both naphthoquinones presented activity against MDR clinical isolates. The combinations with the first-line TB drugs demonstrated an additive effect and \u03b2-lapachone+NAC were synergic against H\n                      <jats:sub>37<\/jats:sub>\n                      Rv. Lapachol activity at acidic pH and its association with NAC improved the selectivity index. Lapachol and \u03b2-lapachone produced cell morphological changes in bacilli at pH 6.0 and 6.8, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lapachol revealed promising anti-TB activity, especially associated with NAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2020.0164","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T20:49:27Z","timestamp":1607114967000},"page":"924-932","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Antituberculosis Activities of Lapachol and \u03b2-Lapachone in Combination with Other Drugs in Acidic pH"],"prefix":"10.1177","volume":"27","author":[{"given":"Andressa Lorena","family":"Ieque","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayalla Corr\u00eaa de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biosciences &amp; Physiopatology, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Pietrowski","family":"Baldin","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biosciences &amp; Physiopatology, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathally Claudiane de Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biosciences &amp; Physiopatology, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana Ferreira","family":"Costacurta","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elo\u00edsa Gibin","family":"Sampiron","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Maria Mariano","family":"Fernandez de Andrade","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia Dias","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biosciences &amp; Physiopatology, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katiany Rizzieri","family":"Caleffi Ferracioli","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biosciences &amp; Physiopatology, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosilene Fressatti","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."},{"name":"Postgraduate Program in Biosciences &amp; Physiopatology, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"(in memori","given":"Di\u00f3genes Apar\u00edcio Garcia","family":"Cortez","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Expedito Leite","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regiane Bertin de Lima","family":"Scodro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, State University of Maring\u00e1, Maring\u00e1, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"World Health Organization (WHO). 2019. 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