{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:01:38Z","timestamp":1780369298488,"version":"3.54.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    The aim of this work was to assess the prevalence of carbapenemase-producing and extended-spectrum \u03b2-lactamase-producing Enterobacterales (ESBLPE) intestinal carriage among private dwelling residents (PDR) and nursing home residents (NHR) from the catchment area of Hospital Verge de la Cinta (Tortosa. North-Eastern Spain), and to depict clinicoepidemiological features of colonized individuals. Prevalence of ESBLPE carriage amid 762 PDR (0\u201394 years) who had feces collected for routine culture was 7.3% and 31% among 71 NHR (68\u201398 years) screened upon hospital admission. The mean age of colonized and noncolonized subjects was 30 and 32.8 years in PDR (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.58) and 85 and 87 years in NHR (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.32). The predominant ESBLPE was CTX-M-15-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    (42.8% in PDR and 68.2% in NHR [25% and 86.7% belonging to O25b-ST131 clone;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001]), followed by CTX-M-9-group- and SHV-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    and by CTX-M-15-producing\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae.<\/jats:italic>\n                    Overall, 72.7% of ESBLPE were multidrug resistant and 46.2% carried transferable quinolone determinants. Institutionalization in a nursing home was a risk factor for ESBLPE and extended-spectrum \u03b2-lactamase (ESBL)-producing O25b-ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    carriage in individuals over 67 years (odds ratio 7.7 and 14.1). Previous antibiotic use and skin ulcers were significantly associated with ESBLPE carriage in NHR. Age &lt;25 years in PDR and amoxicillin\/clavulanate exposure in NHR protected against ESBL-producing O25b-ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    colonization. Only two PDR, with known risk factors, bore OXA-48-producing isolates. These results highlight the role of nonhospitalized intestinal carriers, particularly NHR, as ESBLPE reservoirs and the preponderance of CTX-M-15, mainly linked to O25b-ST131 clone, as well as the emergence of carbapenemase-producing Enterobacterales carriers.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0201","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T13:36:41Z","timestamp":1603114601000},"page":"879-888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Extended-Spectrum \u03b2-Lactamase- and Carbapenemase-Producing Enterobacterales Intestinal Carriage Among Outpatients: Microbiological and Epidemiological Differences Between Private Dwelling Residents and Nursing Home Residents"],"prefix":"10.1177","volume":"27","author":[{"given":"Mar Olga","family":"P\u00e9rez-Moreno","sequence":"first","affiliation":[{"name":"Laboratori Cl\u00ednic ICS-Terres de l'Ebre, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Tarragona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Moral-Parras","sequence":"additional","affiliation":[{"name":"Laboratori Cl\u00ednic ICS-Terres de l'Ebre, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Tarragona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie France","family":"Domenech-Spanedda","sequence":"additional","affiliation":[{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Tarragona, Spain."},{"name":"Servei de Medicina Preventiva, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Casacuberta-Barber\u00e0","sequence":"additional","affiliation":[{"name":"Laboratori Cl\u00ednic ICS-Terres de l'Ebre, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Tarragona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Bas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratori Cl\u00ednic ICS-Terres de l'Ebre, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Centelles-Serrano","sequence":"additional","affiliation":[{"name":"Laboratori Cl\u00ednic ICS-Terres de l'Ebre, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, Tarragona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00ed","family":"Vila-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratori Cl\u00ednic ICS-Terres de l'Ebre, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"625170","article-title":"ESBLs: a clear and present danger? 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