{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:31:17Z","timestamp":1777923077516,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Vibrio cholerae<\/jats:italic>\n                    is a waterborne bacterium and can cause epidemic cholera disease worldwide. Continuous monitoring of\n                    <jats:italic toggle=\"yes\">V. cholerae<\/jats:italic>\n                    contamination in aquatic products is imperative for assuring food safety. In this study, we determined virulence, antimicrobial susceptibility, heavy metal tolerance, and genomic fingerprints of 370\n                    <jats:italic toggle=\"yes\">V. cholerae<\/jats:italic>\n                    isolates recovered from 12 species of commonly consumed aquatic products collected from July to September of 2018 in Shanghai, China. Among the species,\n                    <jats:italic toggle=\"yes\">Leiocassis longirostris<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Ictalurus punetaus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Ophiocephalus argus Cantor<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Pelteobagrus fulvidraco<\/jats:italic>\n                    were for the first time detected for\n                    <jats:italic toggle=\"yes\">V. cholerae<\/jats:italic>\n                    . Toxin genes\n                    <jats:italic toggle=\"yes\">ctxAB<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">tcpA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">ace<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">zot<\/jats:italic>\n                    were absent from all the\n                    <jats:italic toggle=\"yes\">V. cholerae<\/jats:italic>\n                    isolates. However, high occurrence of virulence-associated genes was detected, such as\n                    <jats:italic toggle=\"yes\">hapA<\/jats:italic>\n                    (82.7%),\n                    <jats:italic toggle=\"yes\">hlyA<\/jats:italic>\n                    (81.4%),\n                    <jats:italic toggle=\"yes\">rtxCABD<\/jats:italic>\n                    (81.4%, 24.3%, 80.3%, and 80.8%, respectively), and\n                    <jats:italic toggle=\"yes\">tlh<\/jats:italic>\n                    (80.5%). Approximately 62.2% of the 370\n                    <jats:italic toggle=\"yes\">V. cholerae<\/jats:italic>\n                    isolates exhibited resistance to streptomycin, followed by ampicillin (60.3%), rifampicin (53.8%), trimethoprim (38.4%), and sulfamethoxazole-trimethoprim (37.0%). Moreover, \u223c57.6% of the isolates showed multidrug resistant phenotypes with 57 resistance profiles, which was significantly different among the 12 species (multiple antimicrobial resistance index,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Meanwhile, high incidence of tolerance to heavy metals Hg\n                    <jats:sup>2+<\/jats:sup>\n                    (69.5%), Ni\n                    <jats:sup>2+<\/jats:sup>\n                    (32.4%), and Cd\n                    <jats:sup>2+<\/jats:sup>\n                    (30.8%) was observed among the isolates. The enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR)-based fingerprinting profiles classified the 370\n                    <jats:italic toggle=\"yes\">V. cholerae<\/jats:italic>\n                    isolates into 239 different ERIC-genotypes, which demonstrated diverse genomic variation among the isolates. Overall, the results in this study meet the increasing need of food safety risk assessment of aquatic products.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2020.0269","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T12:55:55Z","timestamp":1604667355000},"page":"1526-1539","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Virulence, Resistance, and Genomic Fingerprint Traits of\n                    <i>Vibrio cholerae<\/i>\n                    Isolated from 12 Species of Aquatic Products in Shanghai, China"],"prefix":"10.1177","volume":"26","author":[{"given":"Huiyu","family":"Fu","sequence":"first","affiliation":[{"name":"Key Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), China Ministry of Agriculture, College of Food Science and Technology, Shanghai Ocean University, Shanghai, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), China Ministry of Agriculture, College of Food Science and Technology, Shanghai Ocean University, Shanghai, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Liang","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Kan","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Peng","sequence":"additional","affiliation":[{"name":"Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanming","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), China Ministry of Agriculture, College of Food Science and Technology, Shanghai Ocean University, Shanghai, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"8","article-title":"Vibrio spp","volume":"4","author":"Baker-Austin C.","year":"2018","unstructured":"Baker-Austin C., , Oliver J.D., , Alam M., , Ali A., , Waldor M.K., , Qadri F., , and Martinez-Urtaza J.. 2018. Vibrio spp. infections. Nat. Rev. Dis. Primers, 4:8.","journal-title":"infections. Nat. Rev. Dis. Primers"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4036-x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003832"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00282"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00901"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-018-0113-x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.9.3518-3519.2000"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.021014-0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002049"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1903.121156"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-2011-9"},{"key":"e_1_3_4_13_2","first-page":"7","article-title":"Draft genome sequence of a Non-O1\/O139 Vibrio cholerae strain isolated from a patient presenting with dysuria","volume":"2018","author":"Leong L.E.X.","year":"2018","unstructured":"Leong L.E.X., , Gordon D.L., , and Rogers G.B.. 2018. Draft genome sequence of a Non-O1\/O139 Vibrio cholerae strain isolated from a patient presenting with dysuria. Microbiol. Resour. Announc. 2018:7.","journal-title":"Microbiol. Resour. Announc"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.151996"},{"key":"e_1_3_4_15_2","volume-title":"Vibrio cholerae","author":"Ceccarelli D.","year":"1918","unstructured":"Ceccarelli D., , Chen A., , Hasan N.A., , Rashed S.M., , Huq A., , and Colwell R.R.. 2015. Non-O1\/non-O139 Vibrio cholerae. carrying multiple virulence factors and, V. cholerae, O1 in the Chesapeake Bay, Maryland. Appl. Environ. Microbiol. 81: 1909\u2013, 1918."},{"key":"e_1_3_4_16_2","volume-title":"Vibrio cholerae","author":"Dua P.","unstructured":"Dua P., , Karmakar A., , and Ghosh C.. 2018. Virulence gene profiles, biofilm formation, and antimicrobial resistance of Vibrio cholerae. non-O1\/non-O139 bacteria isolated from West Bengal, India. Heliyon 4: e0, 1040."},{"key":"e_1_3_4_17_2","first-page":"3","article-title":"Genes activated by Vibrio cholerae upon exposure to caenorhabditis elegans reveal the mannose-sensitive hemagglutinin to be essential for colonization","volume":"2018","author":"List C.","year":"2018","unstructured":"List C., , Grutsch A., , Radler C., , Cakar F., , Zingl F.G., , Schild-Prufert K., , and Schild S.. 2018. Genes activated by Vibrio cholerae upon exposure to caenorhabditis elegans reveal the mannose-sensitive hemagglutinin to be essential for colonization. mSphere, 2018:3.","journal-title":"mSphere"},{"key":"e_1_3_4_18_2","first-page":"417","article-title":"Comparative genomics for non-O1\/O139 Vibrio cholerae isolates recovered from the Yangtze River Estuary versus V. cholerae representative isolates from serogroup O1. Mol. Genet","volume":"294","author":"Gong L.","year":"2019","unstructured":"Gong L., , Yu P., , Zheng H., , Gu W., , He W., , Tang Y., , Wang Y., , Dong Y., , Peng X., , She Q., , Xie L., , and Chen L.. 2019. Comparative genomics for non-O1\/O139 Vibrio cholerae isolates recovered from the Yangtze River Estuary versus V. cholerae representative isolates from serogroup O1. Mol. Genet. Genomics, 294:417\u2013430.","journal-title":"Genomics"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05287-8"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.10.010310"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.10.3774-3779.2000"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.053801-0"},{"key":"e_1_3_4_23_2","first-page":"Italy","article-title":"Molecular characterization and drug susceptibility of non-O1\/O139 V","author":"Ottaviani D.","year":"2018","unstructured":"Ottaviani D., , Medici L., , Talevi G., , Napoleoni M., , Serratore P., , Zavatta E., , Bignami G., , Masini L., , Chierichetti S., , Fisichella S., , and Leoni F.. 2018. Molecular characterization and drug susceptibility of non-O1\/O139 V. cholerae strains of seafood, environmental and clinical, origin, Italy. Food Microbiol. 72:82\u201388.","journal-title":"cholerae strains of seafood, environmental and clinical"},{"key":"e_1_3_4_24_2","volume-title":"Phenotypic and genotypic antimicrobial resistance traits of Vibrio cholerae","author":"Lepuschitz S.","unstructured":"Lepuschitz S., , Baron S., , Larvor E., , Granier S.A., , Pretzer C., , Mach R.L., , Farnleitner A.H., , Ruppitsch W., , Pleininger S., , Indra A., , and Kirschner A.K.T.. 2019. Phenotypic and genotypic antimicrobial resistance traits of Vibrio cholerae. non-O1\/non-O139 isolated from a large Austrian lake frequently associated with cases of human infection. Front. Microbiol. 10:2600."},{"key":"e_1_3_4_25_2","volume-title":"Vibrio cholerae","author":"Verma J.","unstructured":"Verma J., , Bag S., , Saha B., , Kumar P., , Ghosh T.S., , Dayal M., , Senapati T., , Mehra S., , Dey P., , Desigamani A., , Kumar D., , Rana P., , Kumar B., , Maiti T.K., , Sharma N.C., , Bhadra R.K., , Mutreja A., , Nair G.B., , Ramamurthy T., , and Das B.. 2019. Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae. Proc. Natl. Acad. Sci. U. S. A. 116: 6226\u2013, 6231."},{"key":"e_1_3_4_26_2","first-page":"14","article-title":"A new strategy for heavy metal polluted environments: a review of microbial biosorbents","volume":"2017","author":"Ayangbenro A.S.","year":"2017","unstructured":"Ayangbenro A.S., , and Babalola O.O.. 2017. A new strategy for heavy metal polluted environments: a review of microbial biosorbents. Int. J. Environ. Res. Public Health, 2017:14.","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-016-1772-0"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-9590-4"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.5194\/aab-62-265-2019"},{"key":"e_1_3_4_30_2","unstructured":"Zhang X. Xiao F. and Li S.M.. 2018. China Fishery Statistics Yearbook 2018. China Agriculture Press Beijing."},{"key":"e_1_3_4_31_2","first-page":"China","article-title":"The mosaic accessory gene structures of the SXT\/R391-like integrative and conjugative elements derived from Vibrio spp","author":"Song Y.","year":"2013","unstructured":"Song Y., , Yu P., , Li B., , Pan Y., , Zhang X., , Cong J., , Zhao Y., , Wang H., , and Chen L.. 2013. The mosaic accessory gene structures of the SXT\/R391-like integrative and conjugative elements derived from Vibrio spp. isolated from aquatic products and environment in the Yangtze River, Estuary, China. BMC Microbiol. 13:214.","journal-title":"isolated from aquatic products and environment in the Yangtze River"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2015.10.062"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2008.05.001"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-009-9524-6"},{"key":"e_1_3_4_35_2","first-page":"e76200","article-title":"Synergistic effect of various virulence factors leading to high toxicity of environmental V","volume":"8","author":"Rajpara N.","year":"2013","unstructured":"Rajpara N., , Vinothkumar K., , Mohanty P., , Singh A.K., , Singh R., , Sinha R., , Nag D., , Koley H., , and Kushwaha Bhardwaj A.. 2013. Synergistic effect of various virulence factors leading to high toxicity of environmental V. cholerae non-O1\/non-O139 isolates lacking ctx gene: comparative study with clinical strains. PLoS One, 8:e76200.","journal-title":"cholerae non-O1\/non-O139 isolates lacking ctx gene: comparative study with clinical strains. PLoS One"},{"key":"e_1_3_4_36_2","volume-title":"Vibrio parahaemolyticus","author":"Hu Q.","unstructured":"Hu Q., , and Chen L.. 2016. Virulence and antibiotic and heavy metal resistance of Vibrio parahaemolyticus. isolated from crustaceans and shellfish in Shanghai, China. J. Food. Prot. 79: 1371\u2013, 1377."},{"key":"e_1_3_4_37_2","first-page":"261","article-title":"Measurement of diversity","volume":"27","author":"Simpson, E.H","year":"1972","unstructured":"Simpson, E.H. 1972. Measurement of diversity. J. Cardiothorac. Vase. Anesth. 27:261.","journal-title":"J. Cardiothorac. Vase. Anesth"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/lam.13162"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02412"},{"key":"e_1_3_4_40_2","first-page":"98","article-title":"Transcriptome sequencing and de novo analysis of the northern snakehead, Ophiocephalus argus","volume":"2019","author":"Xiao M.","year":"2019","unstructured":"Xiao M., , Bao F., , Zhao Y., , and Hu Q.. 2019. Transcriptome sequencing and de novo analysis of the northern snakehead, Ophiocephalus argus. J. Genet. 2019:98.","journal-title":"J. Genet"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2009.03.014"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.99487"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-011-0374-4"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-019-00760-w"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182019000300392"},{"key":"e_1_3_4_46_2","volume-title":"Vibrio cholerae","author":"Lin W.","unstructured":"Lin W., , Fullner K.J., , Clayton R., , Sexton J.A., , Rogers M.B., , Calia K.E., , Calderwood S.B., , Fraser C., , and Mekalanos J.J.. 1999. Identification of a Vibrio cholerae. RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proc. Natl. Acad. Sci. U. S. A. 96: 1071\u2013, 1076."},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1613-1624.2001"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00949-09"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05166-11"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01113-13"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2019.05.011"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01770"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2008.0737"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1411-1422.2005"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b00729"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.07.114"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2012.12.008"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.06.216"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14121504"},{"key":"e_1_3_4_60_2","first-page":"121627","article-title":"Levels and human health risk assessments of heavy metals in fish tissue obtained from the agricultural heritage rice-fish-farming system in China","volume":"2019","author":"Wang J.","year":"2019","unstructured":"Wang J., , Shan Q., , Liang X., , Guan F., , Zhang Z., , Huang H., , and Fang H.. 2019. Levels and human health risk assessments of heavy metals in fish tissue obtained from the agricultural heritage rice-fish-farming system in China. J. Hazard. Mater. 2019:121627.","journal-title":"J. Hazard. Mater"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.22.6503"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.61.8.2898-2904.1995"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2014.1772"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.2.697-703.1991"},{"key":"e_1_3_4_65_2","volume-title":"Vibrio cholerae","author":"Chatterjee S.","unstructured":"Chatterjee S., , Ghosh K., , Raychoudhuri A., , Chowdhury G., , Bhattacharya M.K., , Mukhopadhyay A.K., , Ramamurthy T., , Bhattacharya S.K., , Klose K.E., , and Nandy R.K.. 2009. Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae. isolates from hospitalized diarrheal patients in Kolkata, India. J. Clin. Microbiol. 47: 1087\u2013, 1095."},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.59.2.556-560.1993"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.6.2421-2429.2001"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2020.0269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2020.0269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2020.0269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:38:16Z","timestamp":1777667896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2020.0269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":66,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1089\/mdr.2020.0269"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2020.0269","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}